Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 126, Issue 8, Pages 1413-1422Publisher
WILEY
DOI: 10.1002/jso.27084
Keywords
germline CDH1 mutation; hereditary diffuse gastric cancer; prophylactic gastrectomy
Funding
- National Cancer Institute [P30CA013696]
- Stand Up To Cancer
- DeGregorio Family Foundation
Ask authors/readers for more resources
This study reviewed patients with CDH1 mutation who underwent PTG surgery and found that PTG can be performed safely at high-volume referral centers with good quality of life, although nutritional sequelae persist in some patients.
Background Germline mutation of CDH1 is rare and leads to hereditary diffuse gastric cancer (DGC). Methods Patients (pts) with CDH1 mutation who underwent multidisciplinary counseling followed by open prophylactic total gastrectomy (PTG) by a single surgeon were reviewed. Results Fifty-four pts with a median age of 41 years (16-70 years) underwent PTG between 2006 and 2021. Median operative time was 161 min, and median hospital stay was 7 days (range 6-12). There were 5 complications (9.2%) within 30 days, and two complications (pulmonary embolism and pancreatitis) required readmission. There were no anastomotic leaks. The pathologic analysis of the first 10 pts included the entire gastric mucosa, revealing a median of 15 foci of DGC (range 5-136). The subsequent 44 pts with more limited analysis had a median of 2 foci (range 0-5), and two pts (3.7%) had no foci identified. Median maximum weight loss was 19%. In long-term follow-up (median 4.6 years) of 20 pts, median global QOL was 2.0 (very good), the majority had persistent difficulty with certain foods or liquids, and all stated they would again elect PTG over surveillance endoscopy. Conclusions PTG can be performed safely at high-volume referral centers with very good QOL but nutritional sequelae persist.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available