Role of Polyamines in Molecular Regulation and Cross-Talks Against Drought Tolerance in Plants

Global agricultural demand and the impact of fluctuating climatic conditions including global warming have catastrophically limited crop productivity and immensely outstretched the market value of agricultural products leading to acute inflation. The effect of desiccation or drought stress in plants is manifested at three levels viz. morphological, biochemical, and molecular and plants possess their own molecular and signaling arsenal to combat or ameliorate various stresses. For decades, stress-tolerant cultivars have been investigated and modulation of polyamine (PA) signaling was found to play a major role in attenuating environmental stresses including drought as major abiotic stress. PA metabolism pathways with their ability to crosstalk with both primary and secondary metabolic pathways have been correlated with several other responses such as seed germination, plant growth, development, defense, hormonal regulation, stress tolerance, and crop yield. Recent transcriptomic and metabolomic approaches have expanded the knowledge on the regulation of stress-induced biochemical, molecular, and physiological alterations. To fully comprehend the intricate biochemical network of plant stress physiology, it is necessary to identify exact responses against specific stress stimuli, interpret concurrent epigenetic alterations, and use molecular switching. The present review encompasses recent updates on drought tolerance mechanisms mediated by diverse polyamines playing significant roles in metabolic regulation, oxidative stress management, and systematic stress-reversal signaling. Besides, the drought stress-reversal role of polyamines and their cross-talks with other signaling molecules have also been documented. Gene, enzyme, and transcription factor (TF) functional features were retrieved from the published papers involving transgenic or mutant plants with over-expression or loss-of-function investigations.

Automated summary

Global agricultural demand and fluctuating climatic conditions have severely impacted crop productivity and caused inflation in the agricultural market. Plants have their own molecular and signaling mechanisms to combat drought stress, with polyamine signaling playing a major role. Polyamine metabolism pathways are correlated with various plant responses, such as seed germination, plant growth, defense, hormonal regulation, stress tolerance, and crop yield. Recent transcriptomic and metabolomic studies have enhanced our understanding of stress-induced biochemical and molecular alterations in plants.