4.6 Review

Sodium-glucose cotransporter 2 inhibitor ameliorates high fat diet-induced hypothalamic-pituitary-ovarian axis disorders

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals

Kana Ikegami et al.

Summary: Research has shown that hypothalamic arcuate kisspeptin neurons play a crucial role in regulating gametogenesis and steroidogenesis in mammals by overseeing the pulsatile release of GnRH. These neurons, also known as KNDy neurons, express NKB and Dyn. The article focuses on the cellular and molecular mechanisms underlying GnRH pulse generation, as well as the factors that modulate the activity of KNDy neurons and consequent pulsatile GnRH/LH release in mammals.

FRONTIERS IN NEUROENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Dapagliflozin partially restores reproductive function in MC4R KO obese female mice

Ling Cui et al.

Summary: Obese women often have reproductive dysfunction leading to infertility, and dapagliflozin may improve fertility in obese patients through modulation of hormone levels and gene expression.

JOURNAL OF ENDOCRINOLOGY (2022)

Review Pharmacology & Pharmacy

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

Meena S. Subbarayan et al.

Summary: Neuroinflammation, mediated by CX3CL1/CX3CR1 signaling, plays a significant role in the development and progression of neurodegenerative diseases. CX3CL1 acts as a modulator, reducing inflammatory responses and exerting neuroprotective effects. However, it can also promote neurodegeneration. This review provides an overview of the complex nature of CX3CL1/CX3CR1 signaling in various neurodegenerative diseases.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Endocrinology & Metabolism

Microglial metabolic flexibility: emerging roles for lactate

Katia Monsorno et al.

Summary: Microglia, the resident macrophages of the CNS, have important functions in brain health and disease. Lactate, a crucial metabolite, is emerging as a potential modulator of microglial function and metabolism. Understanding the metabolic control of microglia and its parallels with macrophages can provide insights into brain physiology and pathology.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2022)

Article Biochemistry & Molecular Biology

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

Nicolai Franzmeier et al.

Summary: The BDNFVal66Met mutation in Alzheimer's disease is associated with a greater impact on cognitive impairment, particularly through a decrease in hippocampal-medial-frontal connectivity. This finding was consistent across ADAD patients and elderly individuals with sporadically occurring Aβ, and was linked to lower global cognitive performance.

MOLECULAR PSYCHIATRY (2021)

Article Clinical Neurology

Identification of state‐specific proteomic characteristics of microglia‐derived exosomes

Juliet V Santiago et al.

Alzheimers & Dementia (2021)

Article Immunology

Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

Anna M. Klawonn et al.

Summary: The activation of microglia in neurological diseases, especially in major depression, has been found to be crucial in inducing negative affective states. This is mediated by the microglial production of cytokines and prostaglandins, leading to alterations in the excitability of striatal neurons. Intervention targeting this mechanism could potentially alleviate depressive symptoms in diseases involving microglial activation.

IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity

Yihai Liu et al.

Summary: Empagliflozin can reduce atherosclerotic lesions burden in mice, decrease body weight, lipid profiles, RAAS, and sympathetic activity. However, the anti-inflammatory effect of empagliflozin is not significantly evident.

LIPIDS IN HEALTH AND DISEASE (2021)

Article Multidisciplinary Sciences

Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment

Stephanie Constantin et al.

Summary: Researchers have found that the long-lasting impact of KP on GnRH neurons is regulated by the interaction with nitric oxide signaling, which affects the activity of GnRH neurons and their pulse generation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator

Mayuko Nagae et al.

Summary: The study demonstrates that KNDy neurons serve as the GnRH pulse generator, and at least 20% of KNDy neurons are sufficient to maintain folliculogenesis. This provides a new therapeutic approach for treating infertile women.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Developmental Biology

High-fat diet induces an ovulatory defect associated with dysregulated endothelin-2 in mice

Natalie M. Hohos et al.

Summary: Consumption of a high-fat diet results in ovulatory dysfunction in female rodents, regardless of the development of obesity, which may be mediated through dysregulation of ovarian Edn2 expression.

REPRODUCTION (2021)

Article Endocrinology & Metabolism

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance

Bo Chang et al.

Summary: This study found that moderate exercise can improve the expression of kisspeptin and GnRH in the hypothalamus of obese mice, reduce inflammation levels, and improve sperm quality; while high-load exercise may promote inflammation, affecting the regulation of kisspeptin and the HPT axis.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)

Article Biochemistry & Molecular Biology

Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome

Jacob E. Pruett et al.

Summary: This study investigated the therapeutic effects of empagliflozin on polycystic ovary syndrome (PCOS), showing reductions in obesity and blood pressure, and a decrease in the activity of the renin-angiotensin system. However, the drug had limited effects on blood glucose and renal injury, suggesting the need for additional treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

TLR2-and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner

Simone Schilling et al.

Summary: Activation of microglia by Toll-like receptors can lead to varying levels of neuronal network dysfunction, with severe dysfunction primarily caused by reactive oxygen and nitrogen species rather than proinflammatory cytokines.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Cardiac & Cardiovascular Systems

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) Inhibitors for New-Onset Dementia: A Propensity Score-Matched Population-Based Study With Competing Risk Analysis

Jonathan Mui et al.

Summary: The study found that compared to DPP4I users, SGLT2I users had lower incidences of dementia, Parkinson's disease, and cerebrovascular mortality.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats

Shiori Minabe et al.

Summary: This study reveals that a high-fat diet can suppress Kiss1 and Pdyn gene expressions in male rats, leading to potential infertility, while causing irregular estrous cycles in a portion of female rats. The findings suggest that the effect of obesity on reproductive function may differ between male and female rats, with a potential underlying mechanism involving Kisspeptin neurons in the arcuate nucleus.

PEPTIDES (2021)

Article Multidisciplinary Sciences

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Iain C. Clark et al.

Summary: The study identified microglia-astrocyte interactions and candidate therapeutic targets using RABID-seq, providing new insights into CNS pathology.

SCIENCE (2021)

Article Endocrinology & Metabolism

Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double-blind, phase 2 trial

Susanne Tan et al.

Summary: Licogliflozin can reduce hyperandrogenism and hyperinsulinemia in women with PCOS, potentially representing a promising novel treatment option for the condition.

DIABETES OBESITY & METABOLISM (2021)

Article Endocrinology & Metabolism

Women With Polycystic Ovary Syndrome Have an Increased Risk of Major Cardiovascular Events: a Population Study

Thomas R. Berni et al.

Summary: The study found that young women with PCOS have an increased risk of developing myocardial infarction, angina, and revascularization. Weight gain and type 2 diabetes were identified as modifiable risk factors that can be intervened upon.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Endocrinology & Metabolism

Exenatide, Dapagliflozin, or Phentermine/Topiramate Differentially Affect Metabolic Profiles in Polycystic Ovary Syndrome

Karen E. Elkind-Hirsch et al.

Summary: EQW/DAPA and PHEN/TPM showed the most significant reduction in weight and body fat, as well as improvements in blood glucose levels and insulin sensitivity. All drugs resulted in decreases in fasting glucose, testosterone, FAI, and blood pressure.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Immunology

Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus

Kuan-Hui Ethan Chen et al.

Summary: The study found that male mice fed a high-fat diet experience higher neuroinflammation compared to females, likely due to accumulating more visceral fat which serves as a source of pro-inflammatory macrophages that migrate to other tissues, including the hypothalamus. This new connection between adipose tissue and the hypothalamus in obesity contributes to neuroinflammation and hypothalamic pathologies, shedding light on the male bias for neuroinflammation and metabolic syndrome.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Endocrinology & Metabolism

Obesity induces morphological and functional changes in female reproductive system through increases in NF-κB and MAPK signaling in mice

Xiuxiu Gao et al.

Summary: The increasing incidence of infertility in obese women has become a global health challenge, with evidence suggesting a link between obesity, reproductive dysfunction, and inflammatory status. However, the underlying molecular mechanisms connecting obesity to infertility remain unclear.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)

Article Medicine, General & Internal

Dietary and Physical Activity Habits in Adolescent Girls with Polycystic Ovary Syndrome (PCOS)-HAstudy

Malgorzata Mizgier et al.

Summary: The study found that girls with PCOS had higher fat intake and lower levels of physical activity compared to the control group. Additionally, PCOS patients showed abnormal levels of metabolic and inflammatory markers.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Endocrinology & Metabolism

Women With Polycystic Ovary Syndrome Have an Increased Risk of Major Cardiovascular Events: a Population Study

Thomas R. Berni et al.

Summary: The study found that young women with PCOS have an increased risk of myocardial infarction, angina, and revascularization, with weight and type 2 diabetes being potentially modifiable risk factors.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Neurosciences

Development and sensory experience dependent regulation of microglia in barrel cortex

John Kalambogias et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2020)

Article Cardiac & Cardiovascular Systems

Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention

Olatokunbo Osibogun et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2020)

Article Endocrinology & Metabolism

Inflammation Triggered by Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome

Frank Gonzalez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Pharmacology & Pharmacy

Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice

Byambasuren Ganbaatar et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Immunology

Glioblastoma hijacks microglial gene expression to support tumor growth

Sybren L. N. Maas et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Article Multidisciplinary Sciences

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Louis-Philippe Bernier et al.

NATURE COMMUNICATIONS (2020)

Article Clinical Neurology

The role of microglia in the development of neurodegeneration

Aigul R. Saitgareeva et al.

NEUROLOGICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Emily A. Day et al.

BIOCHEMICAL JOURNAL (2020)

Article Biochemistry & Molecular Biology

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

Phi T. Nguyen et al.

Article Biochemistry & Molecular Biology

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Emanuela Pasciuto et al.

Article Biochemistry & Molecular Biology

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

Ada Ndoja et al.

Article Pharmacology & Pharmacy

Empagliflozin protects heart from inflammation and energy depletion via AMPK activation

Chintan N. Koyani et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Obstetrics & Gynecology

Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis

V Wekker et al.

HUMAN REPRODUCTION UPDATE (2020)

Review Neurosciences

Immunometabolism in the Brain: How Metabolism Shapes Microglial Function

Louis-Philippe Bernier et al.

TRENDS IN NEUROSCIENCES (2020)

Article Cell Biology

Phycocyanin Improves Reproductive Ability in Obese Female Mice by Restoring Ovary and Oocyte Quality

Xin Wen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Endocrinology & Metabolism

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: A randomized controlled study

Zeeshan Javed et al.

CLINICAL ENDOCRINOLOGY (2019)

Review Medicine, Research & Experimental

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet et al.

EMBO MOLECULAR MEDICINE (2019)

Article Medicine, General & Internal

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

V. Perkovic et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Dario Tejera et al.

EMBO JOURNAL (2019)

Review Immunology

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar

JOURNAL OF NEUROIMMUNOLOGY (2019)

Article Immunology

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

Morena Zusso et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Endocrinology & Metabolism

Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner

Irina Milanova et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Cell Biology

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

Jung Dae Kim et al.

CELL METABOLISM (2019)

Article Nutrition & Dietetics

Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

Fiona H. McLean et al.

NUTRITION & METABOLISM (2019)

Article Multidisciplinary Sciences

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al.

NATURE (2019)

Article Multidisciplinary Sciences

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease

Jian Jing Siew et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, General & Internal

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

S. D. Wiviott et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

Hypothalamic-Pituitary-Ovarian Axis Disorders Impacting Female Fertility

Sasha Mikhael et al.

BIOMEDICINES (2019)

Review Biochemistry & Molecular Biology

Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review

K. E. Hopperton et al.

MOLECULAR PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway

V. I. Alexaki et al.

MOLECULAR PSYCHIATRY (2018)

Review Biochemistry & Molecular Biology

An Integrated View of Immunometabolism

Yun Sok Lee et al.

Article Multidisciplinary Sciences

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie Voet et al.

NATURE COMMUNICATIONS (2018)

Review Immunology

The identity and function of microglia in neurodegeneration

Wilbur M. Song et al.

NATURE IMMUNOLOGY (2018)

Review Neurosciences

Microglia in neurodegeneration

Suzanne Hickman et al.

NATURE NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Diabetes Induces Abnormal Ovarian Function via Triggering Apoptosis of Granulosa Cells and Suppressing Ovarian Angiogenesis

Yanqing Wu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Immunology

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Leslie Freeman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

TNFα drives mitochondrial stress in POMC neurons in obesity

Chun-Xia Yi et al.

NATURE COMMUNICATIONS (2017)

Article Developmental Biology

KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS

C. Fergani et al.

REPRODUCTION (2017)

Article Reproductive Biology

High-fat high-sugar diet induces polycystic ovary syndrome in a rodent model

Jacob S. Roberts et al.

BIOLOGY OF REPRODUCTION (2017)

Review Pharmacology & Pharmacy

Microglial M1/M2 polarization and metabolic states

Ruben Orihuela et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Multidisciplinary Sciences

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

Ismini E. Papageorgiou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Clinical Neurology

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

Caroline Baufeld et al.

ACTA NEUROPATHOLOGICA (2016)

Article Medicine, General & Internal

Effect of feeding a high-fat diet independently of caloric intake on reproductive function in diet-induced obese female rats

Mona A. Hussain et al.

ARCHIVES OF MEDICAL SCIENCE (2016)

Article Reproductive Biology

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice

Malgorzata E. Skaznik-Wikiel et al.

BIOLOGY OF REPRODUCTION (2016)

Article Immunology

Microglia activation is associated with IFN-α induced depressive-like behavior

Simone Wachholz et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Article Cell Biology

Microglia energy metabolism in metabolic disorder

Martin J. T. Kalsbeek et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2016)

Article Medicine, Research & Experimental

Long-Term High Fat Diet Has a Profound Effect on Body Weight, Hormone Levels, and Estrous Cycle in Mice

Tandra R. Chakraborty et al.

MEDICAL SCIENCE MONITOR (2016)

Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Clinical Neurology

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline

Daniel Bos et al.

ALZHEIMERS & DEMENTIA (2015)

Article Medicine, General & Internal

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

Bernard Zinman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Anti-Inflammatory Dietary Combo in Overweight and Obese Women with Polycystic Ovary Syndrome

Amany Alsayed Salama et al.

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES (2015)

Article Endocrinology & Metabolism

The Altered Mononuclear Cell-Derived Cytokine Response to Glucose Ingestion Is Not Regulated by Excess Adiposity in Polycystic Ovary Syndrome

Frank Gonzalez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Medicine, Research & Experimental

Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

Nicole Bellefontaine et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Endocrinology & Metabolism

Photoperiodic Co-Regulation of Kisseptin, Neurokinin B and Dynorphin in the Hypothalamus of a Seasonal Rodent

J. Bartzen-Sprauer et al.

JOURNAL OF NEUROENDOCRINOLOGY (2014)

Article Cell Biology

Regional distribution of SGLT activity in rat brain in vivo

Amy S. Yu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

Review Multidisciplinary Sciences

Microglia: Scapegoat, Saboteur, or Something Else?

Adriano Aguzzi et al.

SCIENCE (2013)

Editorial Material Cell Biology

Toll-Like Receptor Signaling

Kian-Huat Lim et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Nutrition & Dietetics

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

Zhen Wang et al.

BRITISH JOURNAL OF NUTRITION (2012)

Article Medicine, Research & Experimental

Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice

David E. G. McNay et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Medicine, Research & Experimental

Obesity is associated with hypothalamic injury in rodents and humans

Joshua P. Thaler et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Nutrition & Dietetics

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

Cameron J. Holloway et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

Article Neurosciences

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

Joel V. Faustino et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity

Xiaoqing Zhang et al.

Article Endocrinology & Metabolism

Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice

DV Tortoriello et al.

ENDOCRINOLOGY (2004)

Article Multidisciplinary Sciences

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

S Mariathasan et al.

NATURE (2004)

Article Clinical Neurology

Broad expression of Toll-like receptors in the human central nervous system

M Bsibsi et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)