Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-α responses to endotoxaemia

Article Neurosciences

Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-α responses to endotoxaemia

Michael J. McKinley et al.

Summary: This study investigated the splanchnic sympathetic nerves' role in enhancing interleukin-10 (IL-10) and suppressing tumour necrosis factor-alpha (TNF) levels in the reflex response to systemic immune challenge. The findings demonstrated that the endogenous anti-inflammatory reflex is mediated by sympathetic efferent fibres running in the splanchnic nerves and controlled by divergent pathways for IL-10 and TNF responses, with neurally driven adrenaline regulating IL-10 and sympathetic nerves acting on abdominal organs restraining TNF.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

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Article Neurosciences

Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation

Kaitlin Murray et al.

Summary: Our study reveals that vagus nerve stimulation can inhibit inflammation, with efferent and afferent stimulation having distinct mechanisms. Immune regulation induced by vagus nerve stimulation is beta(2)-adrenergic receptor-dependent, suggesting unique pathways for controlling immune cell activation through efferent and afferent stimulation.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Medicine, General & Internal

Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19

Eric Azabou et al.

Summary: Despite improved understanding and efforts to produce effective drugs, high death rates among COVID-19 patients persist, leading to the evaluation of pharmacological strategies worldwide. Non-drug therapeutic strategies like vagus nerve stimulation for reducing inflammation and improving outcomes are gaining attention and need further study through clinical trials.

FRONTIERS IN MEDICINE (2021)

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Review Physiology