Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 234, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2022.112546
Keywords
Photodynamic therapy; Photosensitizer; Tissue purging; Cancer therapy; Nanomedicine
Categories
Funding
- Fonds National de la Recherche Scientifique de Belgique-the Excellence of Science (FNRS-EOS) [30443682]
- FNRS-PDR Convention [T.0004.20]
- Fondation Louvain
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Photodynamic therapy (PDT) has gained attention as a selective and minimally invasive cancer therapy strategy. It selectively activates reactive oxygen species (ROS) through the use of photosensitizers (PS), resulting in direct malignant cell death. This makes it a potential ex vivo tissue purging protocol.
The field of photodynamic therapy (PDT) for treating various malignant neoplasms has been given researchers' attention due to its ability to be a selective and minimally invasive cancer therapy strategy. The possibility of tumor cell infection and hence high recurrence rates in cancer patients tends to restrict autologous trans-plantation. So, the photodynamic tissue purging process, which consists of selective photoinactivation of the malignant cells in the graft, is defined as a compromising strategy to purify contaminated tissues before trans-plantation. In this strategy, the direct malignant cells' death results from the reactive oxygen species (ROS) generation through the activation of a photosensitizer (PS) by light exposure in the presence of oxygen. Since new PS generations can effectively penetrate the tissue, PDT could be an ideal ex vivo tissue purging protocol that eradicates cancer cells derived from various malignancies. The challenge is that the applied pharmacologic ex vivo tissue purging should efficiently induce tumor cells with minor influence on normal tissue cells. This review aims to provide an overview of the current status of the most effective PDT strategies and PS development concerning their potential application in ex vivo purging before hematopoietic stem cell or ovarian tissue transplantation.
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