Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 432, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2022.114082
Keywords
Benzo[ h ]chromene; Cell imaging; Fluorescent probe; Hypochlorite
Categories
Funding
- National Natural Science Foundation of China [21907023, 21001040]
- Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province [U1304202]
- Science and Technology Department of Henan Province [212102210033, 212102310388, 222102320069, 222300420523, 212102210646]
- Key Program of Xuchang University [2022CXTD001]
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In this study, a benzo[h]chromene-based probe was developed for the detection of hypochlorite. The probe showed high selectivity and sensitivity towards ClO- and exhibited a rapid response speed and low detection limit. Spectroscopic analysis revealed the oxidation fracture of the probe in the presence of ClO-, leading to the formation of a new compound. The synthesized probe was also successfully used for imaging exogenous and endogenous ClO- in living cells.
In this study, we developed a benzo[h]chromene-based probe (1) for the detection of hypochlorite (ClO-) based on a typical aggregation-induced emission (AIE) output. Probe 1 shows high selectivity and sensitivity toward ClO-, with a rapid response speed (within 10 s) and a low detection limit (246 nM). Sufficient spectroscopic analyses uphold the oxidation fracture of bridge C=C bond with the aid of ClO-, leading to the change of 1 to 2H-benzo[h]chromene-3-carbaldehyde (1a). In addition, the as-synthesized probe was applied in imaging exogenous and endogenous ClO- in living cells.
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