Related references
Note: Only part of the references are listed.Predicting blood-to-plasma concentration ratios of drugs from chemical structures and volumes of distribution in humans
Hideaki Mamada et al.
MOLECULAR DIVERSITY (2021)
In vitro-in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization
Keiichi Morita et al.
XENOBIOTICA (2020)
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs
David A. Tess et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes
Keith A. Riccardi et al.
DRUG METABOLISM AND DISPOSITION (2019)
Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016
Anitha Saravanakumar et al.
CLINICAL PHARMACOKINETICS (2019)
Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Justine Badee et al.
DRUG METABOLISM AND DISPOSITION (2019)
The influence of physicochemical properties on the reactivity and stability of acyl glucuronides
Patrick Camilleri et al.
XENOBIOTICA (2018)
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
Franco Lombardo et al.
DRUG METABOLISM AND DISPOSITION (2018)
Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015
Matthew A. Cerny
DRUG METABOLISM AND DISPOSITION (2016)
An analysis of the attrition of drug candidates from four major pharmaceutical companies
Michael J. Waring et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
In Vitro Metabolism of Montelukast by Cytochrome P450S and UDP-Glucuronosyltransferases
Josiane de Oliveira Cardoso et al.
DRUG METABOLISM AND DISPOSITION (2015)
Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model
Hung-Yen Chin et al.
YONSEI MEDICAL JOURNAL (2014)
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases
Hongbo Zhang et al.
TOXICOLOGY IN VITRO (2012)
A Comprehensive Assessment of Repaglinide Metabolic Pathways: Impact of Choice of In Vitro System and Relative Enzyme Contribution to In Vitro Clearance
Carolina Saell et al.
DRUG METABOLISM AND DISPOSITION (2012)
Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
Peter J. Kilford et al.
DRUG METABOLISM AND DISPOSITION (2009)
The Role of pH in the Glucuronidation of Raloxifene, Mycophenolic Acid and Ezetimibe
Jae H. Chang et al.
MOLECULAR PHARMACEUTICS (2009)
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7
Michael J. Miley et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data:: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
Zoe E. Barter et al.
CURRENT DRUG METABOLISM (2007)
Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases
Kazuharu Okamura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Drug-drug interactions for UDP-glucuronosyltransferase substrates:: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
JA Williams et al.
DRUG METABOLISM AND DISPOSITION (2004)
Acyl glucuronide reactivity in perspective: biological consequences
MJ Bailey et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2003)
In vitro-in vivo correlations for drugs eliminated by glucuronidation:: Investigations with the model substrate zidovudine
S Boase et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
MG Soars et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)