Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 21, Pages 14840-14845Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01290
Keywords
-
Categories
Funding
- National Natural Science Foundation of China
- Project of Central Plains Science and Technology Innovation Leading Talents
- Program for Innovative Research Team in Science and Technology in Universities of Henan Province
- Henan Key Laboratory of Organic Functional Molecules and Drug Innovation
- [U2004189]
- [224200510009]
- [20IRTSTHN005]
Ask authors/readers for more resources
A strategy for a,fi-difunctionalization and C-N bond cleavage of saturated amines with benzo[c]isoxazoles was disclosed, involving B(C6F5)3-catalyzed consecutive hydrogen-borrowing and [4 + 2] cycloaddition followed by a C-N bond cleavage process. The reactions proceed efficiently without the need for oxidants and metal catalysts, providing a broad range of quinoline derivatives in an atom-economical manner.
Herein, we disclose a strategy to realize a,fi-difunctionalization and C-N bond cleavage of saturated amines with benzo[c]isoxazoles via a B(C6F5)3-catalyzed consecutive hydrogen-borrowing and [4 + 2] cycloaddition followed by a C-N bond cleavage process. In general, the reactions proceed efficiently in the absence of any oxidant and metal catalyst to afford a broad range of quinoline derivatives starting from easily accessible substrates in an atom-economical manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available