Blue Light-Mediated, Photocatalyst-Free Decarboxylative Alkylation of Heteroaryl Sulfinimines

We report a diastereoselective, photocatalyst-free decarboxylative alkylation of (hetero)aryl sulfinimines using redox-active esters under blue light. High yields and diastereoselectivities can be achieved under mild conditions, and we demonstrate its utility as a synthetic method, especially for medicinal chemists.

Automated summary

We present a photocatalyst-free, diastereoselective decarboxylative alkylation method for (hetero)aryl sulfinimines using redox-active esters under blue light. This mild and efficient protocol demonstrates its utility as a versatile synthetic tool, especially for medicinal chemists.