Hydrogen Transfer Coupling with 100% Atom Economy: Synthesis of 2-Indolyltetrahydronaphthyridine Derivatives

An iridium-catalyzed hydrogen transfer strategy, enabling straightforward access to tetrahydropyridine derivatives from aryl-1,8-naphthyridines and indolines was developed. This method has unprecedented advantages, including high step economy. In addition, it does not produce any byproducts or require an external high-pressure H-2 gas source. The method offers an important platform for the transformation of 1,8-naphthyridines and indolines into functionalized products.

Automated summary

An iridium-catalyzed hydrogen transfer strategy allows for the straightforward synthesis of tetrahydropyridine derivatives, offering high efficiency and environmental friendliness.