Palladium-Catalyzed Direct Decarbonylative Cyanation of Aryl Carboxylic Acids

The direct transformation of aryl carboxylic acids to aryl nitrile compounds is an interesting topic because carboxylic acids are not only abundant in nature but are also inexpensive and stable. Here, the synthesis of a series of aryl nitriles by palladium catalyzed decarbonylative cyanation of carboxylic acids without base has been achieved. The successful decarbonylative cyanation of drug molecules and Gram-scale reaction to verify the practicality and operability of this method are analyzed.

Automated summary

The direct transformation of aryl carboxylic acids to aryl nitriles has been achieved through palladium-catalyzed decarbonylative cyanation without the use of a base. Successful analysis of the decarbonylative cyanation of drug molecules and gram-scale reactions validates the practicality and operability of this method.