Simple Tandem Olefin Isomerization/Intramolecular Hydroamination of Alkenyl Amines with Various Allylic Tethers

A simple and efficient AgOTf-promoted tandem olefin isomerization/intramolecular hydroamination of 1,1-disub-stituted alkenyl amines has been developed. This one-pot process represents a facile and attractive route for the synthesis of diverse 2-alkyl-substituted 1,3-X,N-heterocycles through chemo-and regiose-lective C(sp3)-N bond formation with atom economy. Advantages such as the operationally simple and practical procedure that uses a readily available catalyst under aerobic conditions, good to excellent chemical yields, the high functional group tolerance, the broad substrate scope, and high efficiency and selectivity are noteworthy.

Automated summary

A simple and efficient one-pot process for the synthesis of diverse 2-alkyl-substituted 1,3-X,N-heterocycles through tandem olefin isomerization/intramolecular hydroamination has been developed. The process utilizes AgOTf catalyst and offers advantages such as high chemical yields, good functional group tolerance, and broad substrate scope.