Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02071
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Funding
- Shandong Medical and Health Science and Technology Development Plan Project
- Science and Technology Development Plan of Tai?an City
- Academic promotion programme of Shandong First Medical University
- Ten-thousand Talents Plan?
- [202013050376]
- [2019GX015]
- [2019LJ003]
- [2019R51012]
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A novel route for the synthesis of derivatives of benzothiadiazine/1-(phenylsulfonyl)-1H-benzimidazole has been developed, utilizing a SnCl2-promoted tandem reduction, ammonolysis, condensation, and deamination reaction. The method offers convenient operation, good functional group tolerance, and employs unsensitive and inexpensive SnCl2/i-PrOH as the reaction reagent, providing a direct approach for the synthesis of pharmaceutically important targets.
A novel route for a SnCl2-promoted tandem reduction, ammonolysis, condensation, and deamination reaction which uses nitrile and 2-nitro-N-phenylbenzenesulfonamide/N-(2-nitrophenyl)benzenesulfonamide to synthesize derivatives of benzothiadiazine/1-(phenylsulfonyl)-1H-benzimidazole has been developed. The method features convenient operation and good functional group tolerance. In addition, it employs unsensitive and inexpensive SnCl2/i-PrOH as the reaction reagent and provides a direct approach for the synthesis of pharmaceutically important targets.
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