Synthesis of Enamines, Aldehydes, and Nitriles from CO2: Scope of the One-Pot Strategy via Formamides

Tetrabutylammonium acetate (TBAA) and Cu(OAc)(2) worked as a binary catalytic system for the solvent-free N-formylation of amines with CO2 and PhSiH3. This catalysis making C-H and C-N bonds with CO2 was coupled with the C-C bond-forming reactions to achieve the one-pot synthesis of enamines, aldehydes, and nitriles. The X-ray crystal structure of a Cu(OAc)(2)-TBAA complex was also revealed.

Automated summary

In this study, TBAA and Cu(OAc)(2) were used as a binary catalytic system for the solvent-free N-formylation of amines with CO2 and PhSiH3. This catalysis not only synthesized enamines, aldehydes, and nitriles, but also formed C-H and C-N bonds, achieving a one-pot synthesis.