4.7 Article

Metal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formations

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume -, Issue -, Pages -

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01292

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Funding

  1. University Grants Commission, New Delhi [F.4 - 5/2018]
  2. SERB-DST, New Delhi [CRG/2020/003773]
  3. Central University of Punjab, Bathinda, for Research Seed Money [CUPB/CC/COE/19/194]
  4. SERB-DST for providing the fellowship

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A mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives was reported. The reaction conditions tolerate a wide range of substrates with various functional groups. Preliminary mechanistic studies suggest that the secondary amine serves as both a C1 source of the amidine group and an aminating agent. The synthetic utility of this method was demonstrated in the late-stage functionalization of drug molecules at the gram scale.
We report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug molecules on the gram scale.

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