Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01292
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Funding
- University Grants Commission, New Delhi [F.4 - 5/2018]
- SERB-DST, New Delhi [CRG/2020/003773]
- Central University of Punjab, Bathinda, for Research Seed Money [CUPB/CC/COE/19/194]
- SERB-DST for providing the fellowship
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A mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives was reported. The reaction conditions tolerate a wide range of substrates with various functional groups. Preliminary mechanistic studies suggest that the secondary amine serves as both a C1 source of the amidine group and an aminating agent. The synthetic utility of this method was demonstrated in the late-stage functionalization of drug molecules at the gram scale.
We report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug molecules on the gram scale.
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