Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 21, Pages 13734-13743Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01403
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Funding
- HRDG (CSIR) , New Delhi
- [09/149 (0820) /2020-EMR-I]
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A series of pyrano[3,2-c]quinolone derivatives were successfully synthesized using taurine as a green bio-organic catalyst and water as the solvent. The protocol offers excellent yields, short reaction times, cost efficiency, atom economy, and easy catalyst recovery and reuse.
A series of pyrano[3,2-c]quinolone derivatives has been synthesized in the presence of taurine (2-aminoethanesulfonic acid) as a green bio-organic catalyst and water as the solvent. The target compounds were synthesized through the three-component reaction between aldehydes, malononitrile/ethylcyanoacetate, and 4-hydroxy-1-methyl-2(1H)-quinolone. The advantages of this protocol are excellent yields of products, short reaction times, cost efficiency, atom economy, and a simple workup procedure with no need for extra purification techniques. Moreover, the catalyst can be easily recovered and reused for up to three cycles without losing any significant activity.
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