Dosimetry in Radiopharmaceutical Therapy

Learning Objectives: On successful completion of this activity, participants should be able to (1) identify the dose (i.e., activity) prescription algorithms for radiophar-maceutical therapy and the advantages and disadvantages of each such algorithm; (2) describe the workflow for patient-specific dosimetry for radiopharmaceutical therapy; and (3) identify the advantages and disadvantages of a-particle emitters for radiopharmaceutical therapy.Financial Disclosure: Intellectual property of Dr. Zanzonico and collaborators has been licensed to Y-mAbs through an agreement between Memorial Sloan Ketter-ing and Y-mAbs. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest.CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www. snmmilearningcenter.org) through October 2025.

Automated summary

This article discusses the dose prescription algorithms, patient-specific dosimetry workflow, and advantages and disadvantages of alpha-particle emitters for radiopharmaceutical therapy.