Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 379, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneumeth.2022.109676
Keywords
Laser -induced breakdown spectroscopy; Elemental imaging; Nanoparticles; Endogenous elements; Brain tissue
Categories
Funding
- Region Auvergne Rhone-Alpes through the Pack Ambition Recherche program (NEPTUNE)
- Ligue Contre le Cancer Foundation (R19ELLEAUME) the LABEX PRIMES [ANR-11-LABX-0063]
- INSERM Cancer [20CP082-00]
- French National Research Agency (ANR) [ANR-16-CE29-0024, ANR-17-CE18-0028, ANR-20-CE17-0021]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE29-0024, ANR-20-CE17-0021, ANR-17-CE18-0028] Funding Source: Agence Nationale de la Recherche (ANR)
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In this study, the application of Laser-Induced Breakdown Spectroscopy (LIBS) in imaging the distribution of chemical elements in brain tissues is explored.
Biological tissues contain various metals and metalloids ions with central role in the regulation of several pathophysiological functions. In parallel, the development and the evaluation of novel nanocompounds for biomedicine require the monitoring of their biodistribution in tissues of interest. Therefore, researchers need to use reliable and accessible techniques to detect and quantify major and trace elements in space-resolved manner. In this communication, we report how Laser-Induced Breakdown Spectroscopy (LIBS) can be used to image the distribution of chemical elements in brain tissues.
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