Journal
JOURNAL OF NEUROSCIENCE
Volume 42, Issue 47, Pages 8807-8816Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0938-22.2022
Keywords
brain criticality; brain dynamics; brain networks; conduction velocities; magnetoencephalography; multiple sclerosis
Categories
Funding
- University of Naples Parthenope Ricerca locale
- European Union's Horizon 2020 Research and Innovation Program
- VirtualBrainCloud [826421]
- Human Brain 570 Project
- [945539 (SGA3)]
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Two structurally connected brain regions are more likely to interact, with the properties of the structural bundles and the topology of the structural connectome affecting the timing of the interactions. Using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles, researchers measured functional delays across the entire human brain and created a topochronic map. The study also found that patients with multiple sclerosis had greater delays across the network compared to controls.
Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain in humans (of either sex) using magneto/electroence-phalography (MEG/EEG) and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracts were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-tract level.
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