Journal
JOURNAL OF NEUROSCIENCE
Volume 42, Issue 42, Pages 7947-7956Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0001-22.2022
Keywords
alpha oscillation; episodic memory; memory consolidation; remote memory; theta oscillation; visual search
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Funding
- National Institute of Neurological Disorders and Stroke Grant [1RF1NS127128-01]
- Krembil Foundation [501100004089]
- Fondation Brain Canada Grant [100009408]
- Whitehall Foundation [100001391]
- Canada Foundation for Innovation
- Alzheimer's Association
- Alzheimer's Society of Canada
- Natural Sciences and Engineering Research Council of Canada [501100000038]
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Research has found that increasing memory age is associated with increased alpha oscillations in the retrosplenial cortex and decreased hippocampocortical synchrony, indicating a potential shift in memory allocation or changes in selection among distributed memory representations in the primate brain.
Memory for events from the distant past relies on multiple brain regions, but little is known about the underlying neural dynamics that give rise to such abilities. We recorded neural activity in the hippocampus and retrosplenial cortex of two female rhesus macaques as they visually selected targets in year-old and newly acquired object-scene associations. Whereas hippocampal activity was unchanging with memory age, the retrosplenial cortex responded with greater magnitude alpha oscillations (10-15 Hz) and greater phase locking to memory-guided eye movements during retrieval of old events. A similar old-memory enhancement was observed in the anterior cingulate cortex but in a beta2/gamma band (28-35 Hz). In contrast, remote retrieval was associated with decreased gamma-band synchrony between the hippocampus and each neocortical area. The increasing retrosplenial alpha oscillation and decreasing hippocampocortical synchrony with memory age may signify a shift in frank memory allocation or, alternatively, changes in selection among distributed memory representations in the primate brain.
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