Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 370, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2022.577930
Keywords
Vaccination; Autoimmunity; Myasthenia gravis; T lymphocyte; B lymphocyte; NK cells; Immunosuppression; Thymectomy
Categories
Funding
- EU [602420]
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This study demonstrates that tetanus toxoid (TT) revaccination does not alter the composition of lymphocyte compartments in myasthenia gravis (MG) patients with stable disease. It also effectively stimulates TT-specific proliferative responses.
Objective: To determine the effect of tetanus toxoid (TT) revaccination on circulating B-, T-and NK-cell com-partments in myasthenia gravis (MG) patients.Methods: Lymphocyte (sub)populations and differentiation stages were assessed by flow cytometry in 50 TT revaccinated MG patients. TT-specific proliferative responses were explored in PBMC cultures. Results: In patients treated with azathioprine B-and NK cell numbers were strongly decreased. Lymphocyte (sub) populations remained unaffected upon TT revaccination. t All patients showed a significant TT-induced prolif-erative response.Conclusion: TT revaccination is effective in MG patients with stable disease irrespective of their thymectomy status and medication and does not alter the composition of the lymphocyte compartment.
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