Journal
JOURNAL OF NEUROENDOCRINOLOGY
Volume 34, Issue 10, Pages -Publisher
WILEY
DOI: 10.1111/jne.13201
Keywords
fertility; kisspeptin; neurokinin B; reproduction
Categories
Funding
- MRC Clinical Research Training Fellowship [MR/T006242/1]
- NIHR Imperial Biomedical Research Centre
- NIHR Senior Investigator Award
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This review focuses on the latest research on reproductive neuropeptides kisspeptin and neurokinin B, highlighting their potential applications in managing reproductive disorders.
The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility. Alongside the tachykinin neurokinin B and the endogenous opioid dynorphin, these peptides are central to the hormonal control of reproduction. Building on the expanding body of experimental animal models, interest has flourished with human studies revealing that kisspeptin administration stimulates physiological reproductive hormone secretion in both healthy men and women, as well as patients with common reproductive disorders. In addition, emerging therapeutic roles based on neurokinin B for the management of menopausal flushing, endometriosis and uterine fibroids are increasingly recognised. In this review, we focus on kisspeptin and neurokinin B and their potential application as novel clinical strategies for the management of reproductive disorders.
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