4.5 Review

Emerging systemic treatment options in meningioma

Related references

Note: Only part of the references are listed.
Article Oncology

Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial

Antonio Omuro et al.

Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.

NEURO-ONCOLOGY (2023)

Article Oncology

Trabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)

Matthias Preusser et al.

Summary: This randomized study on recurrent WHO grade 2 or 3 meningioma patients showed that intravenous trabectedin did not improve progression-free survival (PFS) and overall survival (OS) compared to local standard of care (LOC), and was associated with higher toxicity. Tumor DNA methylation class was identified as an independent prognostic factor for OS.

NEURO-ONCOLOGY (2022)

Review Oncology

Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review

Katherine Belanger et al.

Summary: In this retrospective analysis, the efficacy of TMZ chemoradiation for the treatment of high-grade and recurrent meningiomas was compared to historical controls. The results showed no significant difference in PFS and OS between the two groups, suggesting that further research is needed to find novel treatment methods for malignant and recurrent meningiomas.

BMC CANCER (2022)

Review Clinical Neurology

Prognostic impact of genetic alterations and methylation classes in meningioma

Anna S. Berghoff et al.

Summary: Meningioma-relevant mutations and DNA methylation clusters were investigated and found to have correlations with patient survival times. TRAF7, KLF4, and TRAKL mutation genotypes were associated with improved prognosis. DNA methylation clusters showed better prognostic discrimination than individual mutations. Molecular profiling could facilitate more precise prognostic assessment and identification of potential targets for personalized therapy in meningioma patients.

BRAIN PATHOLOGY (2022)

Article Oncology

Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter

Michael Lim et al.

Summary: The study evaluated the addition of the immune checkpoint inhibitor nivolumab (NIVO) to radiotherapy (RT) + temozolomide (TMZ) in newly diagnosed glioblastoma patients and found that it did not improve survival in these patients.

NEURO-ONCOLOGY (2022)

Article Multidisciplinary Sciences

Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas

Priscilla K. Brastianos et al.

Summary: In a phase 2 clinical trial, pembrolizumab, a PD-1 inhibitor, demonstrated safety and efficacy in patients with high-grade meningiomas. The study achieved its primary endpoint of 6 months progression-free survival and showed promising efficacy in a subset of these tumors. Further research is needed to identify the biological factors that drive response to immune-based therapies in meningioma.

NATURE COMMUNICATIONS (2022)

Article Otorhinolaryngology

Early phase clinical studies of AR-42, a histone deacetylase inhibitor, for neurofibromatosis type 2-associated vestibular schwannomas and meningiomas

D. Bradley Welling et al.

Summary: Two pilot studies of AR-42 in NF2, VS, and meningiomas showed good efficacy and safety. Tumor volumes and growth rates varied in response to treatment. At a 40-mg dose, AR-42 concentrated in tumors and suppressed growth pathways, indicating potential effectiveness.

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY (2021)

Article Oncology

Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2enegative advanced breast cancer: final overall survival results from SOLAR-1

F. Andre et al.

Summary: The study confirmed a certain efficacy in overall survival when alpelisib was added to fulvestrant treatment in patients with PIK3CA-mutated hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer, prolonging the median survival time.

ANNALS OF ONCOLOGY (2021)

Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018

Quinn T. Ostrom et al.

Summary: The report from CBTRUS provides the most up-to-date population-based data on primary brain tumors in the United States, including incidence rates, mortality rates, and survival rates for both malignant and non-malignant tumors.

NEURO-ONCOLOGY (2021)

Article Oncology

Role of 3D volume growth rate for drug activity evaluation in meningioma clinical trials: the example of the CEVOREM study

Thomas Graillon et al.

Summary: This study aimed to improve drug activity assessment in meningioma clinical trials by analyzing the 3D volume growth rate (3DVGR), and found that lesions sensitive to treatment had better outcomes compared to insensitive ones. The classification based on 3DVGR response could provide a more accurate evaluation of drug activity in tumors with volume stabilization and rare response in aggressive meningiomas.

NEURO-ONCOLOGY (2021)

Article Biochemical Research Methods

Crispr/Cas-based modeling of NF2 loss in meningioma cells

Natalie Waldt et al.

Summary: Alterations of the NF2 gene are common in meningiomas, and this study used Crispr/Cas gene editing to create paired meningioma cells with or without NF2. NF2-deficient cells showed reduced apoptosis and larger colonies, and treatment with a FAK inhibitor decreased colony sizes, providing insights for potential therapeutic strategies. This novel model offers a valuable tool for studying the functional consequences and therapeutic approaches related to NF2/merlin loss in meningiomas.

JOURNAL OF NEUROSCIENCE METHODS (2021)

Article Oncology

Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas

Jacky Yeung et al.

Summary: Malignant meningiomas are enriched with immunosuppressive myeloid cells. Treatment with anti-CSF1/CSF1R antibodies may be an effective normalization cancer immunotherapy for malignant meningiomas.

NEURO-ONCOLOGY (2021)

Article Multidisciplinary Sciences

A clinically applicable integrative molecular classification of meningiomas

Farshad Nassiri et al.

Summary: Meningiomas, the most common primary intracranial tumor in adults, often require surgery due to lack of effective medical therapies. This study introduced four consensus molecular groups of meningioma, which accurately predicted clinical outcomes and informed therapeutic options. Single-cell RNA sequencing revealed inter-individual variations in meningioma biology, highlighting the importance of molecular classification in guiding treatment strategies.

NATURE (2021)

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Article Oncology

EANO guideline on the diagnosis and management of meningiomas

Roland Goldbrunner et al.

Summary: Meningiomas are common intracranial tumors with varied management approaches due to limited controlled clinical trials. Advances in molecular genetics have helped refine diagnostic and therapeutic approaches. Neuroimaging is typically used for provisional diagnosis, with surgery often required for definitive diagnosis according to WHO classification.

NEURO-ONCOLOGY (2021)

Article Clinical Neurology

Meningioma metastases: incidence and proposed screening paradigm

Cecilia L. Dalle Ore et al.

JOURNAL OF NEUROSURGERY (2020)

Review Biochemistry & Molecular Biology

Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments

Kuo-Shyang Jeng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Alliance A071401: Phase II trial of FAK inhibition in meningiomas with somatic NF2 mutations.

Priscilla Kaliopi Brastianos et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Neurosciences

KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

Niklas von Spreckelsen et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Letter Clinical Neurology

CDKN2A/Bhomozygous deletion is associated with early recurrence in meningiomas

Philipp Sievers et al.

ACTA NEUROPATHOLOGICA (2020)

Article Neurosciences

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Sarah Findakly et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Article Clinical Neurology

Analysis of the inflammatory tumor microenvironment in meningeal neoplasms

Anna Sophie Berghoff et al.

CLINICAL NEUROPATHOLOGY (2020)

Article Biochemistry & Molecular Biology

Cytokines in the Treatment of Cancer

Kevin C. Conlon et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2019)

Article Oncology

Systemic and local immunosuppression in patients with high-grade meningiomas

Yuping D. Li et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

Article Oncology

Analysis of CDKN2A gene alterations in recurrent and non-recurrent meningioma

Anne Guyot et al.

JOURNAL OF NEURO-ONCOLOGY (2019)

Article Clinical Neurology

Genomic Analysis of Posterior Fossa Meningioma Demonstrates Frequent AKT1 E17K Mutations in Foramen Magnum Meningiomas

Sally R. Williams et al.

JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE (2019)

Article Multidisciplinary Sciences

DNA methylation-based classification of central nervous system tumours

David Capper et al.

NATURE (2018)

Review Clinical Neurology

Advances in meningioma genetics: novel therapeutic opportunities

Matthias Preusser et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

AKT Inhibition in Solid Tumors With AKT1 Mutations

David M. Hyman et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Oncology

Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu J. Han et al.

JOURNAL OF NEURO-ONCOLOGY (2016)

Article Oncology

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma

Malak Abedalthagafi et al.

NEURO-ONCOLOGY (2016)

Review Biotechnology & Applied Microbiology

The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature

Giulia Cossu et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Oncology

Recurrent high-grade meningioma: a phase II trial with somatostatin analogue therapy

Marta Simo et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2014)

Article Genetics & Heredity

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

Priscilla K. Brastianos et al.

NATURE GENETICS (2013)

Article Multidisciplinary Sciences

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

Victoria E. Clark et al.

SCIENCE (2013)

Article Oncology

Hydroxyurea for recurrent surgery and radiation refractory high-grade meningioma

Marc C. Chamberlain

JOURNAL OF NEURO-ONCOLOGY (2012)

Article Oncology

Atypical and anaplastic meningiomas treated with bevacizumab

Lakshmi Nayak et al.

JOURNAL OF NEURO-ONCOLOGY (2012)

Article Oncology

Phase II trials of erlotinib or gefitinib in patients with recurrent meningioma

Andrew D. Norden et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

Article Oncology

Salvage chemotherapy with CPT-11 for recurrent meningioma

Marc C. Chamberlain et al.

JOURNAL OF NEURO-ONCOLOGY (2006)

Article Clinical Neurology

Temozolomide for treatment-resistant recurrent meningioma

MC Chamberlain et al.

NEUROLOGY (2004)

Article Clinical Neurology

Angiogenesis in intracranial meningiomas: immunohistochemical and molecular study

S Pistolesi et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)