Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1267, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2022.133502
Keywords
oxone; indole; benzylamine; bis(indolyl)methanes; arylmethylamines; aerobic
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An environmentally friendly synthesis method for 3,3'-bis(indolyl)methanes (BIMs) has been developed using aryl-methylamines and indoles as substrates under aerobic conditions in the presence of oxone. The synthesis of BIMs using ethanol as a reaction medium represents a practical approach. The method shows good tolerance towards various functional groups and achieves high yields of synthesized BIMs.
An environmentally benign synthesis of 3,3'-bis(indolyl)methanes (BIMs) has been developed from aryl-methylamines and indoles under aerobic condition in presence of oxone. The formation of BIMs using ethanol as a green reaction medium represents a good practical method for synthesis. The good toler-ance was observed towards various functional groups for exploring substrate scope in presence of oxone and the synthesized BIMs afforded in excellent yields up to 94%.(c) 2022 Elsevier B.V. All rights reserved.
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