Anticancer, anti-diabetic, antimicrobial activity of zinc oxide nanoparticles: A comparative analysis

An ecological synthesis of ZnO nanoparticles through a green path from plant leaves extracts have well-known a wind range of application in the field of modern science due to increase drug efficiency, less toxicity and cost effectiveness. In the current study, the synthesis of zinc oxide nanoparticles (ZnO NPs) using the chemical precipitation method and green synthesis method were systematically investigated to determine which method produces the most efficient NPs for antimicrobial, anti-diabetic, and anticancer activity. The green synthesis of ZnO NPs using Vinca rosealeaves extract was carried out. The obtained products were examined using different techniques; UV-Vis, PL spectra, FTIR, XRD, HR-TEM, and SEM. The results showed that XRD, SEM, and TEM confirmed the presence of ZnO nanoparticles with high pu-rity, hexagonal in shape, and ranged in size from 16 to 41 nm. In addition, the anticancer activity of both ZnO NPs MCF-7 (breast cancer) cell line was evaluated. From the assay, green synthesis of ZnO nanoparti-cles has shown better cytotoxic activity than chemical precipitation of ZnO nanoparticles, and it also has excellent anti-diabetic and antimicrobial activity. Both samples of alpha-amylase inhibitors are selective and effective. Sam ple GS-ZnO NPSs showed maximum efficiency of alpha-amylase inhibition (84.37%), minimum efficacy of CS-ZnO NPs (83.85%) due to the presence of alkaloids. In addition, GS-ZnO NPs (81.75 mu g/mL) showed a strong cytotoxic effect against the MCF7 cell line. The result suggested that ZnO nanoparticles synthesized using the green route showed more effective antimicrobial activity, anti-diabetic activity, and anticancer activity than chemical precipitation methods. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

In this study, ZnO nanoparticles were synthesized through green synthesis and chemical precipitation methods. The results showed that the green synthesis method produced nanoparticles with higher antimicrobial, anti-diabetic, and anticancer activities compared to the chemical precipitation method. The green synthesized nanoparticles exhibited high purity, hexagonal shape, and a size range of 16-41 nm.