4.6 Article

Syntheses, crystal structures, hirshfeld surface analyses and electrochemical etoposide/camptotechin sensor applications of acetaldehyde oxime derivatives

Journal

JOURNAL OF MOLECULAR STRUCTURE
Volume 1265, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.molstruc.2022.133339

Keywords

Oxime; Crystal structure, Hirshfeld surface analysis; Electrochemical sensor, Etoposide; Camptotechin

Ask authors/readers for more resources

Two oxime compounds were synthesized and their crystal structures analyzed. The crystal packings were determined by hydrogen bonding and van der Waals interactions, suggesting potential use of these compounds in sensor applications.
(E)-2-(4-Hydroxyphenyl)-2-oxoacetaldehyde oxime monohydrate (I) and (E)-2-(4 Nitropheny1)-2oxoacetaldehyde oximes (II) were synthesized from 4'-hydroxyacetophenone and 4'-nitroacetophenone, respectively. Their structures were elucidated by elemental analyses, H-1 NMR, UV-Vis and also their molecular and crystal structures were determined by single crystal X-ray analysis. They belong to monoclinic system P 2(1)/n space group with a = 6.8198 (3) angstrom, b = 7.3846 (3) angstrom, c = 16.4706 (5) angstrom, beta = 94.300 (3)degrees, Z = 4 and V = 827.15 (6) angstrom(3) (for I) and a = 7.1557 (3) angstrom, b = 14.5338 (5) angstrom, c = 8.6311 (3) angstrom, beta = 108.321 (3)degrees, Z = 4 and V = 852.13 (5) angstrom(3) (for II). Hirshfeld surface analyses of the crystal structures indicate that the most important contributions for the crystal packings are from H center dot center dot center dot H (35.0%) and H center dot center dot center dot O/O center dot center dot center dot H (33.9%) contacts (for I) and H center dot center dot center dot O/O center dot center dot center dot H (40.9%) and H center dot center dot center dot H (19.4%) contacts (for II). Hydrogen bonding and van der Waals contacts are the dominant interactions in the crystal packings. Comparing the limit of detection achieved in this work with the therapeutic ranges of etoposide/camptotechin verifies the possibility of using both oxime I and II based electrodes as sensors. However GCPE/I electrode exhibited the best electrochemical improvement on the etoposide determination in terms of both sensitivity and limit of detection (C) 2022 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available