Synthesis, characterization, anti-bacterial and anticancer activities of Palladium(II) mixed ligand complexes of 2-mercapto-5-methyl-1,3,4-thiadiazole (HmtzS) and phosphines. Crystal structure of [Pd(mtzS)2(dppf)].H2O.EtOH

Two thione and thionate based complexes were synthesized by simply reacting the ligand 2-mercapto-5-methyl-1,3,4-thiadiazole (HmtzS) with palladium(II) salt in a neutral or basic medium in 2:1 mo-lar ratio. Reacting of resulting complex [Pd(mtzS)(2)] (2) with Ph2P(CH2)nPPh(2) (n = 1-4), dppf, Ph3P or Ph3PS yielded mononuclear complexes, [Pd(mtzS)(2)(Ph2P(CH2) nPPh(2))] (3-5), [Pd(mtzS)2(dppf)] (6), [Pd(mtzS)2(Ph3P)(2)] (7) or [Pd(mtzS)(2)(Ph3PS)(2)] (8). An X-ray structure of [Pd(mtzS)(2)(dppf)] (6) shows that the mtzS ligand is now coordinated in a monodentate fashion via the sulfur atom.. The prepared com-plexes were screened against Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aurous, Escherichia coli and S. typhi. Moreover the cytotoxicity of the prepared complexes were evaluated against colon mam-malian cancer (LoVo) and breast cancer (MCF-7) cell lines by MTT assay. Results shows that complexes exhibited cytotoxicity with IC50 values within (9.7 +/- 1.2) to (39.1 +/- 7.6) }IM range against LoVo and within (8.8 +/- 1.4) to (40.2 +/- 2.6) }IM range against MCF-7 cell lines. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

Two thione and thionate based complexes were synthesized by reacting the ligand 2-mercapto-5-methyl-1,3,4-thiadiazole with palladium(II) salt. The prepared complexes exhibited activity in bacterial screening and cytotoxicity evaluation.