Adsorption of doxorubicin hydrochloride onto thermally treated green adsorbent: Equilibrium, kinetic and thermodynamic studies

The mango seeds activated carbon (MSAC) nanoparticles were created because these materials have high biocompatibility and might be used as a medication carrier. The anti-cancer medication doxorubicin hydrochloride (DOX) was loaded on MSAC nanoparticles in this study was characterized by the XRD, SEM, and BET showed that the surface area being 443 m(2)/g while pore volume was 0.649 cm3/g. The doxorubicin technique was applied performance factors, contact period, pH, concentration, adsorbent dose, and temperature were all examined to evaluate DOX adsorption. Greatest DOX adsorption on MSAC found to be at a pH of 5. This shows that, because to the outstanding components employed in the MSAC structure, the existing difficulty of employing larger doses of doxorubicin could be effectively mitigated. The created approach significantly enhanced DOX adsorption, indicating that the produced nanocomposite might be used to deliver drugs. The adsorption process of MSAC was at its optimum of 0.25 mmol/g, and the adsorption isotherm fit to the Langmuir model, while fitted to pseudo-second-order model for adsorption kinetics. DOX adsorption on MSAC is endothermic and spontaneous, according to thermodynamic studies.(C) 2022 Elsevier B.V. All rights reserved.

Automated summary

In this study, mango seeds activated carbon (MSAC) nanoparticles were prepared with high biocompatibility for potential use as drug carriers. The experimental results showed that the nanocomposite significantly enhanced the adsorption performance of the anti-cancer drug DOX, indicating its potential in drug delivery applications.