Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 361, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2022.119596
Keywords
Quercetin; Curcumin; In vitro release; UV-visible spectroscopy; Differential Pluse Voltammetry; Fluorescence spectroscopy
Funding
- Science & Engineering Research Board, Department of Science and Tecnology (SERB-DST) , New Delhi, India
- CSIR, New Dehli for Junior Research Fellowship
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In this study, the solubilization of two natural hydrophobic drugs, Quercetin and Curcumin, was investigated in Pluronics and Pluronics-Labrasol mixed micelles. The results showed that the solubility of both drugs was significantly higher in Pluronic P84 and P84-Labrasol mixed micelles compared to other systems. The enhanced solubilization was supported by fluorescence titrations and dynamic light scattering.
In present work, the solubilization of two natural hydrophobic drugs Quercetin (QCT) and Curcumin (CUR) has been systematically investigated in Pluronics (P84, F127, F68) and Pluronics-Labrasol mixed micelles. UV-Visible studies confirmed that the solubility, drug loading efficiency, partition coefficient (P), standard free energy of solubilization (Delta G degrees) of QCT and CUR were significantly higher in Pluronic P84 and P84-Labrasol mixed micelles than other investigated systems. Solubilization locus of both drugs in pluronic and Pluronic-Labrasol mixed micelles was scrutinized by employing DPV measurments. Enhanced solubilization of both drugs in Pluronic P84 and P84-Labrasol mixed micellar solution is also well supported by increased fluorescence intensity in respective fluorescence titrations. Inferences from Dynamic light scattering (DLS) studies revealed that the hydrodynamic diameter (D-h) of Pluronic-Labrasol mixed micelles is smaller than pure Pluronic micelles. Upon the inclusion of QCT and CUR, D-h of both Pluronic and Pluronic-Labrasol mixed micelles was found to be increased. Pluronic and Pluronic-Labrasol mixed micellar formulations exhibited the sustained release behaviour for both QCT and CUR. The improved solubilization of QCT and CUR may serve as an efficient system for sustained drug delivery enabling enhanced oral absorption and bioavailability. (C) 2022 Elsevier B.V. All rights reserved.
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