Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 360, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2022.119561
Keywords
AgNPs; Wound dressing; Activated carbon; MTT assay; Cell viability; Antimicrobial activity
Funding
- Nano-Convergence Foundation - Ministry of Science and ICT(MSIT, Korea)
- Ministry of Trade, Industry and Energy (MOTIE, Korea) [R202001110]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021H1D3A2A02096291]
- National Research Foundation of Korea (NRF) - Korea government (Ministry of Education) [2021H1D3A2A02096291]
- Korea Evaluation Institute of Industrial Technology (KEIT) [R202001110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2021H1D3A2A02096291] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Wound dressings containing silver nanoparticles have been found to be effective in preventing bacterial infection and promoting wound healing. The preparation of silver nanoparticles with a uniform core-shell structure of poly(tannic acid) showed high antimicrobial activity, although their cytotoxicity hindered practical applications. The addition of natural cell viability enhancers significantly improved cell viability and increased the antimicrobial performance against bacteria. Integrating the prepared nanoparticles into activated carbon fibers for wound-dressing application showed excellent performance compared to commercial products.
Wound dressings are considered to be effective barriers against bacterial attack. They also facilitate wound healing in nursing-management functions. Silver nanoparticles (AgNPs) in wound dressings could overcome the problems associated with bacterial immunity, which is often observed in the use of conventional drugs. In the present work, a high concentration of cost effective and environmentally friendly AgNPs (16.3 +/- 3.7 nm) with a uniform core-shell of poly(tannic acid) (PTA) was prepared. The preparation in high yield (95.8%) was based on an autoxidation-reduction reaction that was induced based on pH-responsive reduction affinity of tannic acid (TA). Despite the high antimicrobial activity of the prepared AgNPs@PTA, their cytotoxicity hindered their practical applications. The addition of different concentrations of natural cell viability enhancers, including TA and chitosan, to the prepared AgNPs@PTA solution improved significantly the cell viability. We have succeeded in improving the half maximal inhibitory concentration (IC50) from 1 to 1000 ppm with minimal cytotoxicity toward L929 cells and 99.99% antimicrobial performance against both E. coli and S. aureus. Finally, the prepared AgNPs@PTA was integrated in an activated carbon fibers for wound-dressing application and exhibited excellent performance when compared with some commercial wound-dressing products. (C) 2022 Published by Elsevier B.V.
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