Leukotriene metabolism and proiflammatory cytokines in Crimean Congo hemorrhagic fever

Article Pharmacology & Pharmacy

Immunobiology of Crimean-Congo hemorrhagic fever

Sergio E. Rodriguez et al.

Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.

ANTIVIRAL RESEARCH (2022)

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Article Microbiology

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

David W. Hawman et al.

Summary: A DNA-based vaccine was shown to protect non-human primates from Crimean-Congo haemorrhagic fever virus-mediated disease, eliciting potent immune responses. This evidence supports clinical development of the vaccine to protect groups at risk for infection.

NATURE MICROBIOLOGY (2021)

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Review Hematology

Disseminated intravascular coagulation: epidemiology, biomarkers, and management

Kasper Adelborg et al.

Summary: Disseminated intravascular coagulation (DIC) is a systemic activation of the coagulation system, leading to microvascular thrombosis and hemorrhage. Underlying conditions like infection, cancer, or obstetrical complications initiate and propagate the DIC process. Timely and accurate diagnosis and treatment of DIC and its underlying causes are essential for prognosis.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Dissecting lipid metabolism alterations in SARS-CoV-2

Ilaria Casari et al.

Summary: Lipid metabolism plays a crucial role in the pathogenesis of the novel coronavirus, with circulating lipids directly correlating to disease severity. Metabolomic and lipidomic approaches provide new insights into potential therapeutic targets for COVID-19.

PROGRESS IN LIPID RESEARCH (2021)

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Review Microbiology

The Role of Lipid Metabolism in Influenza A Virus Infection

Yong Zhou et al.

Summary: Influenza A virus (IAV) is an important zoonotic pathogen that relies on host cell metabolic systems to complete its life cycle. Host cells regulate their metabolic processes to prevent IAV replication, and lipid metabolism modification is expected to limit IAV infection.

PATHOGENS (2021)

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Article Public, Environmental & Occupational Health

Risk of Crimean Congo haemorrhagic fever virus (CCHFV) introduction and spread in CCHF-free countries in southern and Western Europe: A semi-quantitative risk assessment

Angela Fanelli et al.

Summary: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral zoonotic disease caused by CCHFV. This study conducted a semi-quantitative risk assessment on the likelihood of CCHFV entry and exposure in 9 CCHF-free countries in Southern and Western Europe, finding that the majority of countries had low risk, with France and Italy having medium risk.

ONE HEALTH (2021)

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Article Multidisciplinary Sciences

Development of double antibody sandwich ELISA as potential diagnostic tool for rapid detection of Crimean-Congo hemorrhagic fever virus

Neha Shrivastava et al.

Summary: A rapid and sensitive double antibody based antigen capture ELISA has been developed for the detection of Crimean-Congo hemorrhagic fever virus (CCHFV), with high specificity and sensitivity. The assay could detect viral nucleoprotein in different matrices including human serum, ticks, and culture supernatant, showing a detection limit of 25 ng of purified antigen. Comparisons with real time RT-PCR and a commercial kit utilizing gamma irradiated CCHFV demonstrated 100% sensitivity and specificity of the newly developed sandwich ELISA.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Liquid-liquid phase separation in human health and diseases

Bin Wang et al.

Summary: LLPS plays a vital role in the formation of membraneless organelles, physiological functions, and disease development. Advances in research methods provide opportunities for deeper understanding of LLPS. It is crucial to stay informed about recent developments in the field to translate current knowledge into therapeutic discoveries.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Microbiology

Lipid droplets and lipid mediators in viral infection and immunity

Ebony A. Monson et al.

Summary: Lipid droplets play crucial roles in cellular physiology and pathophysiology, regulating lipid storage, protein sequestration, and serving as hubs for integrating metabolic and inflammatory processes in response to cellular stress.

FEMS MICROBIOLOGY REVIEWS (2021)

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Review Biochemistry & Molecular Biology