4.7 Article

SARS-CoV-2-encoded inhibitors of human LINE-1 retrotransposition

Related references

Note: Only part of the references are listed.
Article Biophysics

1H,13C and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: the N-terminal domain-SUD-N

Angelo Gallo et al.

Summary: nsP3 is the largest multi-domain protein encoded by SARS-CoV-2 RNA, with SUDs observed for the first time in SARS-CoV and possibly playing a crucial role in viral replication and interaction with host cells.

BIOMOLECULAR NMR ASSIGNMENTS (2021)

Article Immunology

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Mehdi Moustaqil et al.

Summary: The study revealed that the proteases NSP3 and NSP5 of SARS-CoV-2 can cleave proteins involved in host immune responses, shedding light on the mechanisms behind enhanced inflammatory responses in COVID-19 patients. The direct cleavage of specific proteins by these proteases provides insights into the pathophysiology of the disease.

EMERGING MICROBES & INFECTIONS (2021)

Article Biochemistry & Molecular Biology

A Biochemical Perspective of the Nonstructural Proteins (NSPs) and the Spike Protein of SARS CoV-2

Francis K. Yoshimoto

Summary: The global pandemic in 2020 was caused by the virus SARS CoV-2, with discussions on the chemistry of its various nonstructural proteins and the significance of variant strains. The emerging strains like D614G, 501Y.V1, and 501Y.V2 show structural changes that increase infectivity, emphasizing the need for continued efforts in researching and understanding this rapidly evolving virus.

PROTEIN JOURNAL (2021)

Article Immunology

Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human Cells

Ying Yin et al.

Summary: The study suggests that coronavirus infections can lead to increased retrotransposon expression, potentially causing genome instability and more severe symptoms, especially in cancer patients and the elderly. Additionally, the interaction between coronaviruses and retrotransposons may result in viral fragment invasion of the human genome, leading to more severe disease outcomes.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Microbiology

Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Yan Li et al.

Summary: This study investigated the impact of enteroviral infection on L1 mobility, revealing that different enteroviruses can block L1 transposition. Additionally, viral proteins EV-D68 2A, 3A, 3C, and EV-A71 ORF2p were identified as inhibitors of L1 activity.

FRONTIERS IN MICROBIOLOGY (2021)

Article Medicine, Research & Experimental

SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements

Jez L. Marston et al.

Summary: Research indicates that SARS-CoV-2 infection can lead to the upregulation or downregulation of TE transcripts, with differential expression of these TEs causing differences between specific virus families. In patients with COVID-19, TE overexpression was observed in bronchoalveolar lavage fluid and downregulation was seen in PBMCs.

JCI INSIGHT (2021)

Article Multidisciplinary Sciences

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

Liguo Zhang et al.

Summary: Researchers have found that SARS-CoV-2 RNA may be reverse-transcribed and integrated into the DNA of human cells, leading to positive PCR results in patients even after infection and recovery. However, the integrated viral sequences mainly consist of subgenomic sequences, which cannot produce infectious virus.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Microbiology

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells

Anja Schobel et al.

Summary: HCV infection increases levels of endogenous L1 protein and restricts retrotransposition of engineered L1 reporter elements by inducing stress granules.

PLOS PATHOGENS (2021)

Article Cell Biology

No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing

Nathan Smits et al.

Summary: The study proposed that SARS-CoV-2 hijacks the LINE-1 retrotransposition machinery, but no evidence of virus integration into the genome was found in infected cells. Experiments demonstrated reliable resolution of retrotransposon and exogenous virus insertions by ONT sequencing, suggesting SARS-CoV-2 integration events are extremely rare in vivo and unlikely to drive oncogenesis or explain post-recovery detection of the virus.

CELL REPORTS (2021)

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Editorial Material Medicine, General & Internal

Interpreting Diagnostic Tests for SARS-CoV-2

Nandini Sethuraman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Biochemistry & Molecular Biology

The molecular virology of coronaviruses

Ella Hartenian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Human TRIM5α senses and restricts LINE-1 elements

Bianca Volkmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Architecture of a SARS-CoV-2 mini replication and transcription complex

Liming Yan et al.

NATURE COMMUNICATIONS (2020)

Letter Biochemistry & Molecular Biology

A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins

Jing Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biology

Virus-induced transposable element expression up-regulation in human and mouse host cells

Marissa G. Macchietto et al.

LIFE SCIENCE ALLIANCE (2020)

Article Biochemistry & Molecular Biology

HIV-1 Vpr and p21 restrict LINE-1 mobility

Koudai Kawano et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Engineered LINE-1 retrotransposition in nondividing human neurons

Angela Macia et al.

GENOME RESEARCH (2017)

Review Genetics & Heredity

Restricting retrotransposons: a review

John L. Goodier

MOBILE DNA (2016)

Article Multidisciplinary Sciences

Characterisation of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells

Akira Shimizu et al.

SCIENTIFIC REPORTS (2014)

Article Genetics & Heredity

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

John L. Goodier et al.

PLOS GENETICS (2012)

Article Biochemistry & Molecular Biology

Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

Yi Xie et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

Nicole G. Coufal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Endogenous non-retroviral RNA virus elements in mammalian genomes

Masayuki Horie et al.

NATURE (2010)

Article Microbiology

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

Mickael Bouvet et al.

PLOS PATHOGENS (2010)

Review Biochemistry & Molecular Biology

Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health

Victoria P. Belancio et al.

GENOME RESEARCH (2008)

Article Biochemistry & Molecular Biology

Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles

Deanna A. Kulpa et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Hot L1s account for the bulk of retrotransposition in the human population

B Brouha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Determination of L1 retrotransposition kinetics in cultured cells

EM Ostertag et al.

NUCLEIC ACIDS RESEARCH (2000)