Alterations in vaginal microbiota among pregnant women with COVID-19

Article Developmental Biology

Placental deficiency during maternal SARS-CoV-2 infection

Ebru Celik et al.

Summary: Maternal anti-SARS-CoV-2 Spike antibodies can be transmitted to neonates, and the severity of the infection is associated with placental abnormalities and adverse pregnancy outcomes.

PLACENTA (2022)

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Article Obstetrics & Gynecology

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study

Ipek Gurol-Urganci et al.

Summary: This study found that SARS-CoV-2 infection at the time of birth is associated with higher rates of adverse maternal and perinatal outcomes, including fetal death, preterm birth, preeclampsia, and emergency cesarean delivery. Pregnant women infected with SARS-CoV-2 should be prioritized for vaccination to reduce these risks.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Review Infectious Diseases

Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis

Francesca Di Toro et al.

Summary: The impact of COVID-19 on pregnant women and neonates needs further research. While there are adverse outcomes reported in some cases, the majority of patients have a mild clinical course and the infection does not significantly affect pregnancy outcomes.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Letter Obstetrics & Gynecology

A specific bacterial DNA signature in the vagina of Australian women in midpregnancy predicts high risk of spontaneous preterm birth (the Predict1000 study)

Matthew S. Payne et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Pediatrics

Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios

Dustin D. Flannery et al.

Summary: Efficient transplacental transfer of SARS-CoV-2 IgG antibodies supports the potential for maternally derived antibodies to provide neonatal protection from SARS-CoV-2 infection. This cohort study assesses the association between maternal and neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody concentrations.

JAMA PEDIATRICS (2021)

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Article Medicine, General & Internal

The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis

Shu Qin Wei et al.

Summary: Infection with COVID-19 during pregnancy may lead to an increased risk of preeclampsia, preterm birth, and other adverse pregnancy outcomes. Severe cases of COVID-19 are particularly associated with higher risks of complications such as preeclampsia, preterm birth, gestational diabetes, and low birth weight.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Pediatrics

Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection The INTERCOVID Multinational Cohort Study

Jose Villar et al.

Summary: This study evaluated the risks associated with COVID-19 in pregnancy on maternal and neonatal outcomes compared with pregnant individuals without COVID-19, finding that pregnant individuals with COVID-19 were at higher risk for various complications such as preeclampsia, severe infections, and preterm birth. The findings emphasize the importance for pregnant individuals and clinicians to strictly implement recommended COVID-19 preventive measures.

JAMA PEDIATRICS (2021)

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Review Microbiology

Vaginal microbiome: normalcy vs dysbiosis

Viqar Sayeed Saraf et al.

Summary: The vaginal microflora plays a crucial role in maintaining a normal physiological environment and ensuring reproductive success, with lactobacilli dominating in women of European descent. Changes in the vaginal microbiome during pregnancy can impact pre-term labor and other conditions. Probiotics have shown success in treating bacterial vaginosis and restoring a healthy microbiome.

ARCHIVES OF MICROBIOLOGY (2021)

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Article Obstetrics & Gynecology

Pregnancy as a risk factor for severe coronavirus disease 2019 using standardized clinical criteria

Megan C. Oakes et al.

Summary: The study found that pregnant women with symptomatic coronavirus disease 2019 are at significantly increased risk of severe disease compared with nonpregnant women, using nonadmission-based, standardized clinical criteria.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

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Editorial Material Medicine, General & Internal