Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 50, Issue 9, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/03000605221122741
Keywords
Myelodysplastic syndrome; acute myeloid leukemia; myelodysplasia-related changes; mixed phenotype acute leukemia; flow cytometry; genic mutation
Funding
- Natural Science Foundation of Zhejiang Province [LY19H290003]
- Zhejiang Provincial Medical and Health Science and Technology Project [2020KY196]
- Foundation of Zhejiang Province Chinese Medicine Science and Technology Planes [2020ZA04]
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This case report describes a rare diagnostic dilemma of mixed phenotype acute leukemia and acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). The patient was initially diagnosed with myelodysplastic syndrome but progressed to acute leukemia with blast cells expressing both T-lymphoid and myeloid antigens. Cytogenetic analysis and next-generation sequencing confirmed the diagnosis of AML-MRC with the mixed T/myeloid phenotype. After several cycles of treatment, remission was achieved using an ALL-like regimen.
A rare but clinically important diagnostic dilemma arises when cases meet the criteria for both acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) and mixed phenotype acute leukemia, especially those that evolve from myelodysplastic syndrome. We describe a 56-year-old male patient who presented with cytopenias and was initially diagnosed with myelodysplastic syndrome with single lineage dysplasia. Nearly 1 year later, this patient progressed to acute leukemia, and his blast cells simultaneously expressed T-lymphoid and myeloid antigens. Cytogenetic analysis showed a 20q deletion, and next-generation sequencing showed mutations of ASXL1, NRAS, PHF6, RUNX1, TP53, and PIGA. He was diagnosed with AML-MRC with blasts of the mixed T/myeloid phenotype according to the latest World Health Organization guidelines. In accordance with the treatment principles of AML-MRC, we chose an AML-like regimen for four cycles, but the patient did not achieve remission. Finally, we adhered to the treatment principles of mixed phenotype acute leukemia, and he achieved remission after a course of ALL-like regimen chemotherapy.
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