Cardiovascular effects of TMAO and other toxic metabolites of the intestinal microbiome

Article Medicine, General & Internal

Associations of plasma TMAO and its precursors with stroke risk in the general population: A nested case-control study

Dong Liu et al.

Summary: This study found that increased levels of plasma TMAO were associated with higher stroke risk, while its precursors, including carnitine, choline, betaine, and TML, were not associated.

JOURNAL OF INTERNAL MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency

Eun Sil Kim et al.

Summary: This study reveals the association between CTRP9 gene deficiency and gut microbiota distribution in patients with atherosclerosis, confirms the influence of gut microbiota on the progression of atherosclerosis, and suggests restoring gut microbial homeostasis as a potential therapeutic strategy.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

Add to Collection

Review Clinical Neurology

Cerebrovascular Disease, Cardiovascular Disease, and Chronic Kidney Disease: Interplays and Influences

J. David Spence et al.

Summary: This review examines the reasons for the high cardiovascular risk in patients with chronic kidney disease (CKD) and explores alternative treatments to reduce cardiovascular disease (CVD) in CKD. In addition to traditional risk factors, CKD patients are exposed to uremic toxins, including systemically derived toxins and gut-derived uremic toxins. Approaches to reducing these uremic toxins include diet, kidney transplantation, more intensive dialysis, and vitamin therapy.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2022)

Add to Collection

Review Neurosciences

Reducing the Risk of Stroke in Patients with Impaired Renal Function: Nutritional Issues

J. David Spence

Summary: Patients with renal failure are at extremely high cardiovascular risk, with a 10-fold increased risk of stroke compared to the general population. Besides traditional risk factors, toxic substances accumulation also plays a role. To reduce stroke risk, it is important to limit meat intake, avoid egg yolk, and use methylcobalamin.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

Add to Collection

Article Nutrition & Dietetics