Insights From Studies of the Genetics, Pathogenesis, and Immunogenicity of the Varicella Vaccine

While the varicella vaccine was created with approaches established for other live attenuated viral vaccines, novel methods to probe virus-host interactions have been used to explore the genetics, pathogenesis, and immunogenicity of the vaccine compared to wild-type varicella-zoster virus (VZV). As summarized here, a mechanism-based understanding of the safety and efficacy of the varicella vaccine has been achieved through these investigations.

Automated summary

This article summarizes the use of novel methods to explore the genetics, pathogenesis, and immunogenicity of the varicella vaccine compared to wild-type varicella-zoster virus (VZV). Through these investigations, a mechanism-based understanding of the safety and efficacy of the varicella vaccine has been achieved.