Comparison of clinical characteristics of COVID-19 in pregnant women between the Delta and Omicron variants of concern predominant periods

Review Obstetrics & Gynecology

Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants

Winnie Fu et al.

Summary: Vaccination with COVID-19 vaccines during pregnancy and lactation is safe, immunogenic, and effective in preventing COVID-19 disease.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2022)

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Letter Medicine, General & Internal

Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves

Caroline Maslo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Medicine, General & Internal

Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications

Torri D. Metz et al.

Summary: This study aimed to evaluate the association between SARS-CoV-2 infection and serious maternal morbidity or mortality from obstetric complications. The results showed that SARS-CoV-2 infection was associated with an increased risk of serious complications related to obstetric complications.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Sarah J. Stock et al.

Summary: Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. However, this study reveals low levels of vaccination uptake by pregnant women compared to women in the general population and that not being vaccinated is associated with increased risk of severe complications of COVID-19 in pregnancy, including perinatal mortality.

NATURE MEDICINE (2022)

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Letter Medicine, General & Internal

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa

Shirley Collie et al.

Summary: Preliminary data from a test-negative study design in South Africa showed that two doses of the BNT162b2 vaccine had an efficacy of 50 to 70% against hospitalization caused by the omicron variant in Gauteng province.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Immunology

The Effectiveness of the Two-Dose BNT162b2 Vaccine: Analysis of Real-World Data

Gabriel Chodick et al.

Summary: The study evaluated the real-world effectiveness of the BNT162b2 vaccine in Israel, showing a significantly reduced incidence of infection during the protection period compared to the reference period. The vaccine demonstrated 90% effectiveness in preventing infection and 94% effectiveness against COVID-19, with lower efficacy observed in immunosuppressed elderly individuals.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Public, Environmental & Occupational Health

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

Mark G. Thompson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Infectious Diseases

Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in tshwane, south africa

F. Abdullah et al.

Summary: This study analyzed the clinical data of COVID-19 patients admitted to a hospital in Tshwane during the Omicron wave, and found that the severity of the disease was decreased compared to previous waves, with lower death rates and ICU admissions.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study

Cristina Menni et al.

Summary: This study investigated the differences in symptom prevalence, risk of hospital admission, and symptom duration between omicron and delta variants of the SARS-CoV-2 virus. The study found that loss of smell was less common in omicron infections, sore throat was more common, and the rate of hospital admission was lower.

LANCET (2022)

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Article Acoustics

Maternal and perinatal outcomes of SARS-CoV-2 infection in unvaccinated pregnancies during Delta and Omicron waves

P. Birol Ilter et al.

Summary: This study compares pregnancy outcomes of unvaccinated women infected with SARS-CoV-2 during the Delta and Omicron waves. The study found that infection during the Delta wave was associated with increased need for oxygen support and higher maternal mortality. Disease severity and pregnancy complications were similar between the Omicron wave and the pre-Delta period.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2022)

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Review Immunology

Updates on Coronavirus Disease 2019 in Children in Japan

Yuta Aizawa et al.

Summary: This review provides updates on COVID-19 in children in Japan, including the waves of outbreaks, changes in clinical features, and vaccination rates. Despite the impact on children, the clinical outcomes in Japan have been favorable compared to some other countries, and there is a need to improve the vaccination rate.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

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Article Immunology

Secondary Attack Rate, Transmission and Incubation Periods, and Serial Interval of SARS-CoV-2 Omicron Variant, Spain

Javier Del Aguila-Mejia et al.

Summary: Contact tracing data in Cantabria, Spain during December 2021 revealed that the SARS-CoV-2 Omicron variant had a higher transmission rate (39% secondary attack rate) compared to the Delta variant (26% secondary attack rate), regardless of vaccination status. The incubation and serial interval periods were also shorter. Half of the Omicron transmissions occurred before symptom onset in the index case-patient.

EMERGING INFECTIOUS DISEASES (2022)

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Article Immunology

Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan

Nobuaki Matsunaga et al.

Summary: This study in Japan examined hospitalized patients with COVID-19, finding that they are typically middle-aged males with close contact to confirmed or suspected cases. The most common comorbidities were hypertension and diabetes. Most patients admitted were nonsevere cases, with a majority not requiring oxygen support during hospitalization.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal

Racial and Ethnic Disparities in COVID-19-Related Infections, Hospitalizations, and Deaths A Systematic Review

Katherine Mackey et al.

Summary: African American/Black and Hispanic populations in the U.S. have higher rates of SARS-CoV-2 infections, hospitalizations, and COVID-19-related mortality compared to non-Hispanic White populations. However, case fatality rates are similar. Health care access and exposure risks may contribute to the observed disparities.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Racial Disparities in COVID-19 Testing and Outcomes Retrospective Cohort Study in an Integrated Health System

Gabriel J. Escobar et al.

Summary: Racial disparities exist in outcomes after SARS-CoV-2 infection, with race being the most important predictor of infection and associated with increased hospitalization risk but not mortality. Adjusted analyses showed no racial differences in inpatient mortality or total mortality during the study period.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Association Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women

Inbal Goldshtein et al.

Summary: The retrospective cohort study found that BNT162b2 mRNA vaccination in pregnant women was associated with a significantly reduced risk of SARS-CoV-2 infection compared to no vaccination. However, interpretation of the study findings is limited by the observational design.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Characteristics and Outcomes of Women With COVID-19 Giving Birth at US Academic Centers During the COVID-19 Pandemic

Justine Chinn et al.

Summary: This study compared characteristics and outcomes of women who underwent childbirth with vs without COVID-19 in a large US cohort, and found that women with COVID-19 during childbirth had higher rates of mortality, intubation, ICU admission, and preterm birth.

JAMA NETWORK OPEN (2021)

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Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 and Pregnancy Outcomes According to Gestational Age at Time of Infection

Dominique A. Badr et al.

Summary: The study examined the impact of SARS-CoV-2 infection during pregnancy on obstetric and neonatal outcomes, finding statistically significant increases in adverse outcomes for both mothers and babies. It suggests that vaccination programs should target women early in pregnancy or before conception to prevent these risks.

EMERGING INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal