Single-cell RNA sequencing analysis of liver reveals the enhanced entry and release abilities of human adenovirus F41, partially explaining acute hepatitis in children

Article Biochemistry & Molecular Biology

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Juan Pablo Robles et al.

Summary: COVID-19 causes dysfunction of vascular endothelial cells, leading to edema, vascular inflammation, and coagulation. This study reveals that the spike protein of SARS-CoV-2 activates the inflammatory response in endothelial cells through binding with integrin alpha 5 beta 1, resulting in the expression of inflammatory and coagulation factors, as well as increased vascular permeability and leukocyte adhesion. These findings highlight integrin alpha 5 beta 1 as a potential target for treating vascular inflammation in COVID-19.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Letter Infectious Diseases

Impact of non-pharmaceutical interventions during COVID-19 pandemic on pertussis, scarlet fever and hand-foot-mouth disease in China

Yiman Geng et al.

JOURNAL OF INFECTION (2022)

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Article Multidisciplinary Sciences

Coronavirus, adenovirus, or both? Hepatitis poses mystery

Meredith Wadman

SCIENCE (2022)

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Letter Infectious Diseases

Low incidence rate of diarrhoea in COVID-19 patients is due to integrin

Shan Gao et al.

JOURNAL OF INFECTION (2021)

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Article Virology

Heparan Sulfate Is a Cellular Receptor for Enteric Human Adenoviruses

Anandi Rajan et al.

Summary: This study identified heparan sulfate as an interaction partner for the short fiber of enteric HAdVs, which remains unaffected by acidic pH and enhances attachment to host cells. The research also revealed a switch in receptor usage of enteric HAdVs after exposure to acidic pH.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences