Human infection with H3N8 avian influenza virus: A novel H9N2-original reassortment virus

Letter Infectious Diseases

Wild bird-origin H3N8 avian influenza virus exhibit well adaptation in mammalian host

Yitao Li et al.

JOURNAL OF INFECTION (2022)

Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

Add to Collection

Letter Infectious Diseases

A child with acute respiratory distress syndrome caused by avian influenza H3N8 virus

Dongliang Cheng et al.

JOURNAL OF INFECTION (2022)

Add to Collection

Article Microbiology

Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central China

Zhongzi Yao et al.

Summary: This study conducted a 5-year active surveillance of avian influenza virus (AIV) in wild birds in central China, revealing the long-term circulation and prevalence of AIVs in this region, as well as frequent and continuous intercontinental gene exchange. Spillover events from poultry to wild birds were observed, and some AIV strains showed the ability to bind human-type receptors and replicate in mice without preadaptation. These findings underscore the potential threat of wild bird AIVs to public health.

MICROBIOLOGY SPECTRUM (2022)

Add to Collection

Article Veterinary Sciences

HA gene amino acid mutations contribute to antigenic variation and immune escape of H9N2 influenza virus

Rui Zhu et al.

Summary: This study identified a key amino acid mutation, A180V, in the HA protein of the H9N2 avian influenza virus, which directly caused viral antigenic variation and affected cross-reactivity and immune escape. These findings contribute to a better understanding of the evolution mechanism of the H9N2 virus.

VETERINARY RESEARCH (2022)

Add to Collection

Article Immunology

PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals

Xinghai Zhang et al.

Summary: Influenza H3N8 viruses isolated from wild bird reservoirs have the potential to pose a threat to human health and show varied capabilities of binding to human-type receptors. Experimental studies on guinea pigs indicate efficient transmission of certain viruses without prior adaptation. Mutations such as PB1 S524G were found to confer airborne transmissibility between ferrets.

EMERGING MICROBES & INFECTIONS (2021)

Add to Collection

Letter Infectious Diseases