Journal
JOURNAL OF HUMAN HYPERTENSION
Volume 37, Issue 4, Pages 253-264Publisher
SPRINGERNATURE
DOI: 10.1038/s41371-022-00769-8
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This paper reviews the pathophysiology of hypertension and highlights the multi-omics approaches for hypertension prediction and diagnosis.
Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregulated genes that are linked to hypertension. Moreover, post-genomic biomarkers, from the emerging fields of transcriptomics, proteomics, glycomics and lipidomics, have provided new insights into the molecular underpinnings of hypertension. In this paper, we review the pathophysiology of hypertension, and highlight the multi-omics approaches for hypertension prediction and diagnosis.
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