4.7 Article

Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Early developmental nanoplastics exposure disturbs circadian rhythms associated with stress resistance decline and modulated by DAF-16 and PRDX-2 in C. elegans

Chan-Wei Yu et al.

Summary: The study revealed that early developmental exposure to polystyrene NPs disrupts circadian rhythms in C. elegans, affecting chemotaxis response levels. Furthermore, NPs exposure leads to increased bioaccumulation in entrained worms and production of reactive oxygen species, which are related to disturbed circadian rhythms. The research also showed that the circadian disruption induced by NPs is associated with a decline in stress resistance and is modulated by transcription DAF-16/FOXO signaling.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Chemistry, Multidisciplinary

Increase in germline methyltransferases governing the methylation of histone H3K9 is associated with transgenerational nanoplastic toxicity in Caenorhabditis elegans

Le Zhang et al.

Summary: Long-term exposure to 20 nm polystyrene nanoparticles (PS-NPs) in Caenorhabditis elegans caused transgenerational toxicity, with dysregulation of germline histone methyltransferases (HMTs) including increased expression of MET-2 and SET-6. Knockdown of MET-2 and SET-6, required for methylation of H3K9, affected the transgenerational PS-NP toxicity, highlighting the role of these HMTs in mediating the toxicity after exposure.

ENVIRONMENTAL SCIENCE-NANO (2022)

Review Environmental Sciences

Micro (nano) plastics in wastewater: A critical review on toxicity risk assessment, behaviour, environmental impact and challenges

Simranjeet Singh et al.

Summary: This study aims to contribute towards understanding the behavior of nanoplastics in our environment, specifically through identification of various sources, detection techniques, toxicity estimation, health risk in humans, environmental fate, recovery and reuse, and future challenges and limitations. Detailed review on the toxic effects of nanoplastics on various organisms and their degradation rates in soil and water matrices are provided. The study also discusses the suitability of small- and large-scale separation techniques for the removal of nanoplastics in wastewater treatment plants, as well as current challenges and future perspectives in understanding the fate and transport of nanoplastics in the environment, including research gaps and the importance of reducing, reusing, and recycling plastic products.

CHEMOSPHERE (2022)

Article Environmental Sciences

Multi-walled carbon nanotubes induce transgenerational toxicity associated with activation of germline long non-coding RNA linc-7 in C. elegans

Yingyue Zhao et al.

Summary: This study investigated the transgenerational toxicity of multi-walled carbon nanotubes (MWCNTs) and the role of germline long non-coding RNAs (lncRNAs) in Caenorhabditis elegans. The results showed that exposure to MWCNTs caused transgenerational toxicity in terms of decreased brood size and impaired locomotion behavior. Among germline lncRNAs, expression of 5 lncRNAs was dysregulated by MWCNT exposure. Further analysis revealed that only germline RNAi of linc-7 affected MWCNT toxicity. Germline linc-7 expression was increased transgenerationally, and transgenerational MWCNT toxicity was prevented in linc-7 (RNAi) nematodes. Additionally, germline linc-7 controlled transgenerational MWCNT toxicity by activating downstream transcription factor DAF-12.

CHEMOSPHERE (2022)

Review Toxicology

Microplastics and Their Impact on Reproduction-Can we Learn From the C. elegans Model?

Elysia Jewett et al.

Summary: Biologically active environmental pollutants, such as microplastic and nanoplastic particles, have significant impact on ecosystems, wildlife, and human health. These plastic particles can cause oxidative stress, inflammation, and cellular damage, resulting in reproductive and health issues in animals and humans. However, the full extent of their impact is not yet fully understood, though they carry additional risks through the contaminants and toxic chemicals they transport.

FRONTIERS IN TOXICOLOGY (2022)

Article Engineering, Environmental

Long-term nanoplastics exposure results in multi and trans-generational reproduction decline associated with germline toxicity and epigenetic regulation in Caenorhabditis elegans

Chan-Wei Yu et al.

Summary: The study reveals that long-term exposure to nanoplastics can lead to multi and transgenerational reproductive decline in Caenorhabditis elegans, potentially associated with germline toxicity and epigenetic regulation.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of μg/L in C. elegans

Yunhan Yang et al.

Summary: This study identified the roles of neuronal G alpha proteins GOA-1, GSA-1, and GPA-10 in controlling the response to polystyrene nanoparticles in nematodes. These proteins transduce signals from multiple GPCRs to different downstream signaling pathways, regulating toxicity effects. The findings emphasize the significance of GPCRs-G alpha signaling cascade in neurons for managing nanoplastic responses in organisms.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Size-dependent transgenerational toxicity induced by nanoplastics in nematode Caenorhabditis elegans

Huanliang Liu et al.

Summary: The study compared the transgenerational toxicity of 20 nm and 100 nm polystyrene nanoparticles using Caenorhabditis elegans as a model, finding that exposure to 20 nm particles resulted in more severe toxicity than 100 nm particles due to differences in transgenerational activation of oxidative stress.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Environmental Sciences

Micro- and nanoplastic induced cellular toxicity in mammals: A review

Amrita Banerjee et al.

Summary: Plastic-based products are widely used in daily life but their limited biodegradability has raised pollution concerns globally, particularly micro- and nanoplastics. These pollutants are widespread in various environments and have well-documented biological effects on aquatic organisms, while their impacts on mammals remain insufficiently studied. Small size, positive charge, high dose, and presence of toxic additives or pollutants in micro/nanoplastics appear to induce cellular toxicity through oxidative stress, membrane damage, immune response, and genotoxicity.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Dysregulated mir-76 mediated a protective response to nanopolystyrene by modulating heme homeostasis related molecular signaling in nematode Caenorhabditis elegans

Huanliang Liu et al.

Summary: Our study reveals that neuronal miRNA mir-76 controls nanoplastic toxicity in nematodes by regulating the globin protein GLB-10 in neurons. Moreover, we identified a signaling cascade involving HRG-7 and HRG-5 that is crucial for regulating heme homeostasis and NPS toxicity in organisms.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Engineering, Environmental

What Is on the Outside Matters-Surface Charge and Dissolve Organic Matter Association Affect the Toxicity and Physiological Mode of Action of Polystyrene Nanoplastics to C. elegans

Carolin L. Schultz et al.

Summary: Surface functionalization and eco-corona formation can modulate the toxicity of nanoplastics, altering the potency and order of toxicity. The effects of surface charges on nanoplastic toxicity are primarily linked to differences in effect thresholds and dose-associated damage parameters, rather than toxicokinetic parameters. Eco-corona interactions between particles can reduce toxicity, but the order of potency of charged forms remains consistent.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Environmental Sciences

Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans

Shuting Wang et al.

Summary: Neurotransmission related signals, specifically tyramine and glutamate, play crucial roles in regulating the toxicity of nanoplastics in Caenorhabditis elegans. Tyramine induces toxicity while glutamate alleviates toxicity, with both signals being mediated through neurons. Tyramine receptor TYRA-2 and glutamate receptors GLR-4 and GLR-8 act upstream of specific signaling pathways to regulate nanoplastic toxicity.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Fecal microbiota transplantation attenuates nano-plastics induced toxicity in Caenorhabditis elegans

Qiang Chu et al.

Summary: This study systematically evaluated the toxicity of nano-plastics on C. elegans, and found that human fecal microbiota transplantation can alleviate the toxic effects through activating specific pathways.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Toxicology

Microplastic and nanoplastic transfer, accumulation, and toxicity in humans

P. A. Stapleton

Summary: Plastic micro- and nano-sized particles can enter human life through air and water sources, and even exist in consumable products. This review mainly discusses the pathways of human exposure, toxicological outcomes, and related concerns.

CURRENT OPINION IN TOXICOLOGY (2021)

Article Chemistry, Multidisciplinary

Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure in Caenorhabditis elegans

Yunhan Yang et al.

Summary: The study identified 13 GPCRs involved in controlling nanopolystyrene toxicity in Caenorhabditis elegans, with only PAQR-2 and FSHR-1 acting in the intestine to regulate toxicity. PAQR-2 and FSHR-1 regulate nanopolystyrene toxicity in the intestine by modulating various signaling pathways.

ENVIRONMENTAL SCIENCE-NANO (2021)

Article Chemistry, Multidisciplinary

Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles in Caenorhabditis elegans

Yunhan Yang et al.

Summary: The study revealed that in Caenorhabditis elegans, the germline responds to NPS exposure through a signaling cascade mediated by GPCR CED-1, which may regulate NPS toxicity by affecting the activities of p38 MAPK and insulin signaling pathways in intestinal cells.

NANOSCALE ADVANCES (2021)

Review Environmental Sciences

Micro- and nano-plastics in marine environment: Source, distribution and threats - A review

Licheng Peng et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Review Toxicology

The plastic brain: neurotoxicity of micro- and nanoplastics

Minne Prust et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

Article Environmental Sciences

Epigenetic effects induced by silver nanoparticles in Caenorhabditis elegans after multigenerational exposure

Anye Wamucho et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Environmental Sciences

Regulation of response to nanopolystyrene by intestinal microRNA mir-35 in nematode Caenorhabditis elegans

Dan Li et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Environmental Sciences

Epigenetic response to nanopolystyrene in germline of nematode Caenorhabditis elegans

Yunhan Yang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Article Multidisciplinary Sciences

Construction of a germline-specific RNAi tool in C-elegans

Lina Zou et al.

SCIENTIFIC REPORTS (2019)

Article Environmental Sciences

Mechanical formation of micro- and nano-plastic materials for environmental studies in agricultural ecosystems

A. F. Astner et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Environmental Sciences

Nanopolystyrene-induced microRNAs response in Caenorhabditis elegans after long-term and lose-dose exposure

Man Qu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Marine & Freshwater Biology

Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)

Jordan A. Pitt et al.

AQUATIC TOXICOLOGY (2018)

Article Engineering, Environmental

Multigenerational Study of Gold Nanoparticles in Caenorhabditis elegans: Transgenerational Effect of Maternal Exposure

Shin Woong Kim et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Multidisciplinary Sciences

Autoregulation of microRNA biogenesis by let-7 and Argonaute

Dimitrios G. Zisoulis et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans

Samir Bouasker et al.

NUCLEIC ACIDS RESEARCH (2012)