4.5 Review

Therapeutic approaches of nutraceuticals in the prevention of Alzheimer's disease

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

Marjan Talebi et al.

Summary: Thymoquinone has various pharmacological activities and protective effects on multiple organs and systems, mainly through modulation of the Nrf2 signaling pathway.

PHYTOTHERAPY RESEARCH (2021)

Review Cell Biology

The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?

Vanessa Castelli et al.

Summary: The etiology of neurodegenerative diseases remains unclear, but lifestyle and genetic factors are believed to play a role. Studies have shown that variations in gut microbiota composition and function can impact various human disorders, including neurodegenerative diseases. Nutritional interventions and the use of probiotics have been suggested as potential strategies to modulate gut microbiome dysbiosis and improve biological outcomes, emphasizing the importance of further research into the gut-brain axis and its mechanisms for effective treatment.

NEURAL REGENERATION RESEARCH (2021)

Review Pharmacology & Pharmacy

Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing

Melanie-Jayne R. Howes et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice

Pedram Honarpisheh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation

Alyne Mendonca Marques Ton et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Review Cell Biology

Gut microbiota and pro/prebiotics in Alzheimer's disease

Ryszard Pluta et al.

AGING-US (2020)

Review Endocrinology & Metabolism

Peripheral Immunosenescence and Central Neuroinflammation: A Dangerous Liaison - A Dietary Approach

Thea Magrone et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

Review Biochemistry & Molecular Biology

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Vivian Hook et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Article Medicine, General & Internal

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial

Isabella C. Arellanes et al.

EBIOMEDICINE (2020)

Review Medicine, Research & Experimental

Molecular mechanism-based therapeutic properties of honey

Marjan Talebi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Neurosciences

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

Tiantian Guo et al.

MOLECULAR NEURODEGENERATION (2020)

Review Immunology

Alzheimer's disease: natural products as inhibitors of neuroinflammation

Olumayokun A. Olajide et al.

INFLAMMOPHARMACOLOGY (2020)

Article Public, Environmental & Occupational Health

Vitamin D status, cognitive decline and incident dementia: the Canadian Study of Health and Aging

Caroline S. Duchaine et al.

CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE (2020)

Review Food Science & Technology

Neuro-nutrients as anti-alzheimer's disease agents: A critical review

Sunil K. Ravi et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Article Biochemistry & Molecular Biology

Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

Jit Poddar et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2019)

Review Neurosciences

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

Muneeb U. Rehman et al.

CURRENT NEUROPHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

Judit M. Perez Ortiz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

Stephanie Andrade et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Silymarin's Inhibition and Treatment Effects for Alzheimer's Disease

Hong Guo et al.

MOLECULES (2019)

Review Nanoscience & Nanotechnology

Alzheimer's disease: pathogenesis, diagnostics, and therapeutics

Sneham Tiwari et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yu Yamazaki et al.

NATURE REVIEWS NEUROLOGY (2019)

Review Geriatrics & Gerontology

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Muhammad Ayaz et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Toxicology

Management of oxidative stress and other pathologies in Alzheimer's disease

Miriama Simunkova et al.

ARCHIVES OF TOXICOLOGY (2019)

Article Psychiatry

Coffee intake and decreased amyloid pathology in human brain

Jee Wook Kim et al.

TRANSLATIONAL PSYCHIATRY (2019)

Review Neurosciences

Procyanidins and Alzheimer's Disease

Siqi Zhao et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Food Science & Technology

Medical foods in Alzheimer's disease

Klaus W. Lange et al.

FOOD SCIENCE AND HUMAN WELLNESS (2019)

Review Biochemistry & Molecular Biology

Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

Carmen Rodriguez-Garcia et al.

ANTIOXIDANTS (2019)

Review Cell Biology

Alzheimer's disease pathogenesis: Is there a role for folate?

Natassia Robinson et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

Review Neurosciences

Nutrition and Nutraceuticals in Neuroinflammatory and Brain Metabolic Stress: Implications for Neurodegenerative Disorders

M. D. Pandareesh et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

Editorial Material Pharmacology & Pharmacy

The Neuroprotective Effects of Thymoquinone: A Review

Tahereh Farkhondeh et al.

DOSE-RESPONSE (2018)

Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Chemistry, Medicinal

Beneficial Effects of Flavonoids Against Parkinson's Disease

Un Ju Jung et al.

JOURNAL OF MEDICINAL FOOD (2018)

Review Clinical Neurology

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Miia Kivipelto et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Geriatrics & Gerontology

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

Jin Zhang et al.

IMMUNITY & AGEING (2018)

Review Geriatrics & Gerontology

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

Youngjoo Kwon

EXPERIMENTAL GERONTOLOGY (2017)

Article Clinical Neurology

Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients

Roberto Tiribuzi et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Review Endocrinology & Metabolism

Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease

Rohit Pardeshi et al.

PSYCHONEUROENDOCRINOLOGY (2017)

Review Geriatrics & Gerontology

Botanical Sources for Alzheimer's: A Review on Reports From Traditional Persian Medicine

Ayda Hosseinkhani et al.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2017)

Review Medicine, Research & Experimental

Biophenols pharmacology against the amyloidogenic activity in Alzheimer's disease

Syed Haris Omar

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Food Science & Technology

Nutraceuticals and Functional Foods: The Foods for the Future World

Khalid Gul et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2016)

Review Genetics & Heredity

The genetic landscape of Alzheimer disease: clinical implications and perspectives

Caroline Van Cauwenberghe et al.

GENETICS IN MEDICINE (2016)

Article Clinical Neurology

2016 Alzheimer's disease facts and figures

Alzheimers & Dementia (2016)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

LANCET (2016)

Article Chemistry, Medicinal

Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

Saeed Samarghandian et al.

PHYTOTHERAPY RESEARCH (2016)

Article Neurosciences

Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction

Tina Loeffler et al.

FRONTIERS IN NEUROSCIENCE (2016)

Review Nutrition & Dietetics

Flavonoids: an overview

A. N. Panche et al.

JOURNAL OF NUTRITIONAL SCIENCE (2016)

Review Biochemistry & Molecular Biology

Establishment and Dysfunction of the Blood-Brain Barrier

Zhen Zhao et al.

Article Pharmacology & Pharmacy

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Saeed Ghofrani et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease

Anand Kamal Sachdeva et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Multidisciplinary Sciences

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Michael Willem et al.

NATURE (2015)

Editorial Material Biochemistry & Molecular Biology

Neuro-nutraceuticals: The path to brain health via nourishment is not so distant

Robert J. Williams et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

Article Behavioral Sciences

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

Farideh Asadi et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2015)

Review Neurosciences

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

Miguel Chin-Chan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Plant Sciences

Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice

Jayasingh Chellammal Hanish Singh et al.

PHARMACEUTICAL BIOLOGY (2015)

Article Pharmacology & Pharmacy

Preventing cognitive decline in preclinical Alzheimer's disease

Wim J. Riedel

CURRENT OPINION IN PHARMACOLOGY (2014)

Review Biochemistry & Molecular Biology

Apolipoprotein E Isoforms and Lipoprotein Metabolism

Michael C. Phillips

IUBMB LIFE (2014)

Article Medicine, General & Internal

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease The TEAM-AD VA Cooperative Randomized Trial

Maurice W. Dysken et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Review Neurosciences

Polyunsaturated fatty acids and their metabolites in brain function and disease

Richard P. Bazinet et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Review Behavioral Sciences

Retinoids as potential targets for Alzheimer's disease

Rupinder K. Sodhi et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)

Article Behavioral Sciences

Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction

Anand Kamal Sachdeva et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)

Review Pharmacology & Pharmacy

Nutraceuticals in cognitive impairment and Alzheimer's disease

P. Mecocci et al.

FRONTIERS IN PHARMACOLOGY (2014)

Editorial Material Medicine, General & Internal

New Insights into the Dementia Epidemic

Eric B. Larson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Cell Biology

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Yan Zhao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Review Cell Biology

MicroRNAs and neurodegeneration: role and impact

Masashi Abe et al.

TRENDS IN CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

The protective effect of crocin on the amyloid fibril formation of aβ42 peptide in vitro

Arezou Ghahghaei et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2013)

Article Clinical Neurology

Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease

Holly D. Soares et al.

ARCHIVES OF NEUROLOGY (2012)

Review Biochemistry & Molecular Biology

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

Cesare Mancuso et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Biochemistry & Molecular Biology

Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model

Fang Fang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Review Biochemistry & Molecular Biology

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

Patrizia Mecocci et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Pharmacology & Pharmacy

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

Li-min Chen et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Geriatrics & Gerontology

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

Celeste A. de Jager et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2012)

Article Nutrition & Dietetics

Fruit and vegetable intake and cognitive function in the SU.VI.MAX 2 prospective study

Sandrine Peneau et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)

Review Neurosciences

Amyloid Precursor Protein Processing and Alzheimer's Disease

Richard J. O'Brien et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Article Biochemistry & Molecular Biology

Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers

Joon Ho Ahn et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Review Pharmacology & Pharmacy

Pharma-nutrition interface: The gap is narrowing

Niki A. Georgiou et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

Marcus O. W. Grimm et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Pharmacology & Pharmacy

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

Ana Maria Martin-Moreno et al.

MOLECULAR PHARMACOLOGY (2011)

Review Neurosciences

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Berislav V. Zlokovic

NATURE REVIEWS NEUROSCIENCE (2011)

Article Clinical Neurology

Tau in Alzheimer Disease and Related Tauopathies

K. Iqbal et al.

CURRENT ALZHEIMER RESEARCH (2010)

Article Chemistry, Medicinal

Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase

Maja Katalinic et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Leslie Crews et al.

HUMAN MOLECULAR GENETICS (2010)

Article Clinical Neurology

Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults

Jonathon L. Reay et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2010)

Article Biochemistry & Molecular Biology

Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

Xifei Yang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2010)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Alzheimer's Disease

Henry W. Querfurth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Allergy

Probiotics and allergy in children - An update review

Shih-Jin Pan et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2010)

Article Neurosciences

Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice

Chuanhai Cao et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

Article Clinical Neurology

Age, Alzheimer disease, and brain structure

C. A. Raji et al.

NEUROLOGY (2009)

Review Chemistry, Medicinal

Flavonoids: Prospective Drug Candidates

Luisa Helena Cazarolli et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

Article Neurosciences

Ginkgolides protect against amyloid-β1-42-mediated synapse damage in vitro

Clive Bate et al.

MOLECULAR NEURODEGENERATION (2008)

Article Pharmacology & Pharmacy

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

G. Esposito et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Behavioral Sciences

Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats' memory

Nikolaos Pitsikas et al.

BEHAVIOURAL BRAIN RESEARCH (2007)

Article Neurosciences

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

Toshifumi Matsui et al.

BRAIN RESEARCH (2007)

Article Clinical Neurology

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model

Monica Garcia-Alloza et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)

Article Biochemistry & Molecular Biology

Reductions in levels of the Alzheimer's amyloid β peptide after oral administration of ginsenosides

Feng Chen et al.

FASEB JOURNAL (2006)

Article Biotechnology & Applied Microbiology

Phenolics as potential antioxidant therapeutic agents: Mechanism and actions

MA Soobrattee et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)

Review Neurosciences

Role of retinoid signalling in the adult brain

MA Lane et al.

PROGRESS IN NEUROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

ABAD enhances A beta-induced cell stress via mitochondrial dysfunction

K Takuma et al.

FASEB JOURNAL (2005)

Review Medicine, General & Internal

Probiotics and gastrointestinal diseases

A Sullivan et al.

JOURNAL OF INTERNAL MEDICINE (2005)

Review Multidisciplinary Sciences

Pathways towards and away from Alzheimer's disease

MP Mattson

NATURE (2004)

Review Clinical Neurology

Enzyme-replacement therapy for metabolic storage disorders

RO Brady et al.

LANCET NEUROLOGY (2004)

Article Biochemistry & Molecular Biology

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

JPE Spencer et al.

BIOCHEMICAL JOURNAL (2003)

Article Clinical Neurology

Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease

K Kobayashi et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2003)

Article Biochemistry & Molecular Biology

Interaction between flavonoids and the blood-brain barrier:: in vitro studies

KA Youdim et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Article Geriatrics & Gerontology

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

H Schroeter et al.

NEUROBIOLOGY OF AGING (2002)

Article Clinical Neurology

Does caffeine intake protect from Alzheimer's disease?

L Maia et al.

EUROPEAN JOURNAL OF NEUROLOGY (2002)

Article Biochemistry & Molecular Biology

beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

CS Casley et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Medicine, General & Internal

Anticarcinogenic effect of Panax ginseng CA Meyer and identification of active compounds

TK Yun et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2001)

Review Pharmacology & Pharmacy

Galantamine - A review of its use in Alzheimer's disease

LJ Scott et al.

DRUGS (2000)

Review Plant Sciences

Flavonoids as antioxidants

PG Pietta

JOURNAL OF NATURAL PRODUCTS (2000)