4.7 Article

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

Related references

Note: Only part of the references are listed.
Article Oncology

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer

Joseph E. Grossman et al.

Summary: This pilot feasibility trial investigated the use of patient-derived organoids (PDOs) to guide personalized therapy for pancreatic ductal adenocarcinoma (PDAC). The study found that the drug sensitivity of PDOs can predict the clinical outcome of patients and is correlated with treatment responses.

CLINICAL CANCER RESEARCH (2022)

Letter Gastroenterology & Hepatology

Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids

Joseph F. Lacomb et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

Review Physiology

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

Giulia Biffi et al.

Summary: Efforts to develop anti-cancer therapies have mainly targeted the epithelial compartment, but recent studies have shown the significant influence of cancer-associated fibroblasts (CAFs) in tumor progression. CAFs not only promote cancer cell proliferation, therapy resistance, and immune exclusion, but may also restrain tumor progression in certain contexts. Research on CAFs has focused on their heterogeneity, plasticity, and functions across different cancer types and states, as well as advancements in therapeutic strategies targeting CAFs currently undergoing preclinical and clinical evaluation.

PHYSIOLOGICAL REVIEWS (2021)

Article Multidisciplinary Sciences

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Teresa G. Krieger et al.

Summary: Using single-cell transcriptome analysis, researchers identified a hierarchy of distinct cell states within pancreatic ductal adenocarcinoma (PDAC), including both 'classical' and 'basal-like' cells. They also found that different tumor cell states are connected by a differentiation hierarchy within organoids.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

David Osuna de la Pena et al.

Summary: Personalized cancer medicine lacks custom platforms that mimic the microenvironment of human tissues. The authors developed a highly tuneable ex vivo model of pancreatic cancer based on self-assembly of patient-derived models, showing better reproduction of in vivo drug responses. These findings support the use of tuneable self-assembling platforms in cancer research, paving the way for future precision medicine approaches.

NATURE COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

Pancreatic Tumor Microenvironment Factor Promotes Cancer Stemness via SPP1-CD44 Axis

Palanisamy Nallasamy et al.

Summary: The study revealed that CAFs promote stemness enrichment in PC through the osteopontin/secreted phosphoprotein 1-CD44 axis. Long-term treatment of PC cells with CAF-CM resulted in increased stemness characteristics, indicated by significantly higher levels of CSC markers and enhanced tumorsphere formation.

GASTROENTEROLOGY (2021)

Review Oncology

In Vitro 3D Cultures to Model the Tumor Microenvironment

Fabrizio Fontana et al.

Summary: This review highlights the significance of tumor stroma in cancer biology and treatment research. It emphasizes the importance and advantages of 3D cell culture models. Understanding the interactions between tumor cells and stroma is crucial for disease initiation and progression, as the tumor microenvironment plays a key role in cancer growth, metastasis, and drug resistance.

CANCERS (2021)

Review Medicine, General & Internal

Chemotherapy for pancreatic cancer

Christoph Springfeld et al.

PRESSE MEDICALE (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemistry & Molecular Biology

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

Matteo Ligorio et al.

Article Multidisciplinary Sciences

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Else Driehuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Pathology

Novel prognostic markers within the CD44-stromal ligand network in pancreatic cancer

Oskar Franklin et al.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

K. E. Richards et al.

ONCOGENE (2017)

Article Immunology

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Ohlund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations

Julia Jabs et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

Article Medicine, General & Internal

Pancreatic cancer

Jorg Kleeff et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Review Cell Biology

Microenvironmental regulation of therapeutic response in cancer

Florian Klemm et al.

TRENDS IN CELL BIOLOGY (2015)

Article Biochemical Research Methods

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al.

BIOINFORMATICS (2011)

Article Biochemical Research Methods

Micropilot: automation of fluorescence microscopy-based imaging for systems biology

Christian Conrad et al.

NATURE METHODS (2011)

Editorial Material Oncology

High drug attrition rates-where are we going wrong?

Lisa Hutchinson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

Kazuhiro Kikuta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)