Journal
JOURNAL OF EUKARYOTIC MICROBIOLOGY
Volume 69, Issue 6, Pages -Publisher
WILEY
DOI: 10.1111/jeu.12951
Keywords
apicomplexan; calcium; digestive; lysosome; plant-like vacuole; Toxoplasma gondii; vacuolar compartment; zinc
Categories
Funding
- US National Institutes of Health [AI160610, AI120607, AI096836, AI128356, AI143707]
- UGA and T32 fellowship [T32AI06054]
Ask authors/readers for more resources
The PLVAC of T. gondii, which represents its lysosomal compartment, plays important roles in ion storage and homeostasis, endocytosis, exocytosis, and autophagy.
Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients. T. gondii shares several characteristics with plants including a nonphotosynthetic plastid termed apicoplast and a multivesicular organelle that was named the plant-like vacuole (PLV) or vacuolar compartment (VAC). The name plant-like vacuole was selected based on its resemblance in composition and function to plant vacuoles. The name VAC represents its general vacuolar characteristics. We will refer to the organelle as PLVAC in this review. New findings in recent years have revealed that the PLVAC represents the lysosomal compartment of T. gondii which has adapted peculiarities to fulfill specific Toxoplasma needs. In this review, we discuss the composition and functions of the PLVAC highlighting its roles in ion storage and homeostasis, endocytosis, exocytosis, and autophagy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available