Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 920, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2022.116621
Keywords
HIV; Antiretroviral Drugs; Electrochemical Sensors; Voltammetry; Nanomaterials; Polymers
Categories
Funding
- Water Research Commission (WRC) of South Africa: Sense [REF 85102]
- EU Horizon 2020 ERA -Net Cofund Programme
- National Research Founda- tion (NRF) of South Africa: South African Research Chair Initiative (SARChI) [REF WRC C2019/2020-0008]
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The HIV pandemic has led to the discovery and use of antiretroviral drugs for improving patient well-being and reducing the risk of perinatal transmission of HIV. Electroanalytical techniques, particularly voltammetry, have been widely used for ARV analysis due to their advantages of onsite monitoring and real-time analysis. This review discusses the development and recent advances in detection strategies for ARV drugs and focuses on different types of ARV drugs and their mechanisms.
The high human immune deficiency virus (HIV) pandemic has resulted in the discovery, development, and use of antiretroviral (ARV) drugs not only to improve patient well-being but also to reduce the risk of perinatal transmission of HIV. Due to drug-to-drug interactions, drug resistance, drug toxicity, and counterfeit drugs, there has been an urgent need for the development of portable, sensitive, selective, facile, and reliable detec-tion strategies for ARV analysis in both pharmaceutical and clinical settings. Electroanalytical techniques are of particular interest because they offer the advantages of onsite monitoring of ARV drugs due to their flexible nature and real-time analysis compared to traditional analytical techniques. It is evident from literature dating back a decade ago that voltammetry is the most used electroanalytical technique for ARV analysis. Hence, the present review aims to discuss how detection strategies for ARV have evolved over the years and focus on recent advances in ARV analysis. Furthermore, the review will focus on different types of ARV drugs and their respective mechanisms.
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