Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 76, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jddst.2022.103781
Keywords
Epirubicin (EPI); Silver nanoparticles; Polymer coating; Conjugation; Radioiodination; Tumor targeting
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This study highlights the effective use of silver nanoparticles in improving the tumor targeting efficiency of the chemotherapy agent epirubicin. The nanoparticles were conjugated with epirubicin and radio-iodinated, showing promising results in tumor targeting and imaging. The findings suggest the potential of using these nanoparticles for tumor treatment and imaging.
The current study highlights the effective role of silver nanoparticles in improving the tumor targeting efficiency of epirubicin, chemotherapeutic agent. Regarding this, poly (vinyl alcohol)-coated silver nanoparticles were designed in a particle size of 18 +/- 0.1 nm. Furthermore, poly (vinyl alcohol)-coated silver nanoparticles were conjugated with epirubicin in a conjugation efficiency of 88 +/- 2%. Moreover, both poly (vinyl alcohol)-coated silver nanoparticles and epirubicin-conjugated poly (vinyl alcohol)-coated silver nanoparticles were radio -iodinated using iodine-131 isotope and yielded 90.6 +/- 0.1% and 80 +/- 2%, respectively. Crucially, the comparative in-vivo distribution of radioiodinated poly (vinyl alcohol)-coated silver nanoparticles and epirubicin-conjugated poly (vinyl alcohol)-coated silver nanoparticles were studied in healthy and tumor models. Interestingly, the radioiodinated epirubicin-conjugated poly (vinyl alcohol)-coated silver nanoparticles exhibited reticuloendothelial system (RES) shirking and prolonged blood concentration. In addition, it targeted tumor site by 22.8 +/- 1% ID/g within 1 h post IV injection. Further, the tumor targeting efficiency of the new systemwas confirmed by calculating the tumor to normal tissue and the tumor to blood ratios were 12.67 +/- 0.5 and 1.74 +/- 0.05, respectively at 1 h post IV injection. Consequently, the findings provided the radioiodinated epirubicin-conjugated poly (vinyl alcohol)-coated silver nanoparticles as a new potential approach for tumor targeting with a goal of treatment and/or imaging.
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