Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 33, Issue 8, Pages 3170-3177Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2022.2115285
Keywords
Fumaric acid esters; treatment effect modifier; dimethyl fumarate; registry
Categories
Funding
- AbbVie
- Almirall
- Amgen
- Biogen
- BMS
- Celgene
- Hexal
- Janssen-Cilag
- LEO Pharma
- Eli Lilly
- Medac
- Novartis
- Pfizer
- UCB
- Viatris
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This study examines the effectiveness of fumaric acid esters (FAEs) for the treatment of plaque psoriasis in real-world practice. The results show that FAEs have a favorable response at 12 months, largely independent of patient characteristics. The baseline psoriasis area and severity index (PASI) is the only significant factor affecting the odds of response.
Objectives Fumaric acid esters (FAEs) are a well-established treatment option for long-term therapy of moderate to severe plaque psoriasis. This study examines effectiveness of FAEs for the treatment of plaque psoriasis in real-world practice at 12 months and if patient characteristics affect the odds of clinical response. Methods A descriptive, multivariable logistic regression analysis was conducted in a cohort drawn from the German registry PsoBest. Baseline patient characteristics were assessed as potential treatment effect modifiers. Results 444 patients (mean age 47.0 years, 39.0% female) were eligible for response analysis using nonresponder imputation at month 12. Of these, 39.6% achieved clinical response, i.e. Psoriasis Area and Severity Index (PASI) <= 3 or skin clearance. In logistic regression analysis (R-2 = 0.114), only baseline PASI was a significant factor: patients with PASI < 10 had a 4 times higher odds (p <= .001, OR 4.088), patients with PASI of 10-20 a twofold higher odds of response (p <= .044, OR 1.961) compared to those with PASI > 20. Neither sex, age, body weight, disease duration, comorbidity nor pretreatment had an impact on the odds of response (p > .05). Conclusions FAEs showed a favorable response at 12 months, largely independent of patient characteristics.
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