4.8 Review

Research progress on tumor hypoxia-associative nanomedicine

Related references

Note: Only part of the references are listed.
Review Hematology

A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers

Nitin B. Charbe et al.

Summary: Blood transfusion is crucial in emergencies, but whole blood or red blood cell transfusion has limitations such as nephrotoxicity and vasoconstriction. Oxygen transport through PFC and HBOC poses challenges and promises unique prospects as oxygen carriers.

BLOOD REVIEWS (2022)

Review Pharmacology & Pharmacy

Nano drug delivery system reconstruct tumour vasculature for the tumour vascular normalisation

Qiangwei Liang et al.

Summary: The abnormal structure and function of blood vessels in the tumor microenvironment play a crucial role in tumor development, affecting immunosuppression, chemotherapy drug delivery, and anti-tumor immunity. The normalization of tumor blood vessels presents new opportunities and challenges for improving nanoparticle delivery efficiency and developing innovative combination treatments for cancer.

JOURNAL OF DRUG TARGETING (2022)

Review Engineering, Biomedical

Designing Hypoxia-Responsive Nanotheranostic Agents for Tumor Imaging and Therapy

Huige Zhou et al.

Summary: Hypoxia in solid tumors hinders drug delivery and poses challenges for tumor treatment. Recent research on hypoxia-responsive nanomaterials shows promise in overcoming these obstacles and improving therapeutic efficiency.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Conquering the Hypoxia Limitation for Photodynamic Therapy

Yilin Wan et al.

Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.

ADVANCED MATERIALS (2021)

Article Oncology

Sonodynamic therapy-derived multimodal synergistic cancer therapy

Mimi Xu et al.

Summary: Sonodynamic therapy (SDT) offers a promising approach for non-invasively eliminating solid tumors, and combining it with other therapeutic methods can enhance tumor treatment effects. The potential of SDT-based synergistic therapeutics is highlighted for precision tumor treatment medicine.

CANCER LETTERS (2021)

Review Oncology

Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer

Samuel B. Bader et al.

Summary: Hypoxia refers to insufficient levels of oxygen in biological situations, which can occur in various diseases including cancer. Tumor hypoxia is known to lead to more aggressive and difficult-to-treat diseases. Tumor hypoxia is not static, and dynamic changes in oxygen levels have significant biological consequences.

CANCERS (2021)

Review Pharmacology & Pharmacy

Research progress in tumor targeted immunotherapy

Yuelin Fang et al.

Summary: Tumor-targeted immunotherapy combines targeted therapy and immunotherapy to produce lasting treatment effects, bringing hope for the complete cure of cancer.

EXPERT OPINION ON DRUG DELIVERY (2021)

Review Physics, Applied

Smart transformable nanoparticles for enhanced tumor theranostics

Jinjin Chen et al.

Summary: The physical morphologies of nanoparticles significantly influence their biological behaviors, and smart transformable nanomaterials show great potential in advanced tumor theranostics.

APPLIED PHYSICS REVIEWS (2021)

Review Immunology

Vascular Microenvironment, Tumor Immunity and Immunotherapy

Zachary Lamplugh et al.

Summary: Immunotherapy shows promise in cancer treatment, but solid tumor T cell-based immunotherapy faces challenges due to lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment. The vascular microenvironment plays a crucial role in inducing immune-hostile conditions and resistance to immunotherapy in tumors.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

Nicole A. Seebacher et al.

Summary: The tumour microenvironment (TME) plays a crucial role in cancer drug resistance, involving mechanisms such as altered metabolism, changes in stromal cells, increased autophagy, altered drug delivery, and induction of a cancer stem cell phenotype. There is a vast area for potential research to better understand the interplay between factors within and outside the TME, which is essential for developing new therapeutic strategies less prone to failure due to drug resistance in cancer cells.

ANTIOXIDANTS (2021)

Review Oncology

An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor

Yukari Shirai et al.

Summary: HIF-1 is a critical target for cancer therapy due to its association with hypoxia, malignant phenotype, and therapy resistance in tumors. Recent research has focused on uncovering the molecular mechanisms of HIF-1 activation, identifying HIF-1 activators, and developing anticancer drugs targeting HIF-1.

CANCERS (2021)

Review Chemistry, Multidisciplinary

Normalization of the tumor microvasculature based on targeting and modulation of the tumor microenvironment

Zhipeng Li et al.

Summary: Angiogenesis is crucial for tumor development and anti-angiogenesis has emerged as a promising strategy for cancer treatment. The tumor microenvironment and host stromal cells, as well as abnormal metabolic environment play vital roles in promoting tumor angiogenesis. Targeting and normalizing the tumor vasculature in the TME has become a promising strategy for anti-angiogenesis and anti-tumor therapy.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

Nanoparticles Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy

Shi Gao et al.

ACS NANO (2020)

Review Engineering, Biomedical

Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia

Abhishek Sahu et al.

BIOMATERIALS (2020)

Review Chemistry, Multidisciplinary

Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review

Rashmi Kumari et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Pharmacology & Pharmacy

The role of antibody delivery formation in cancer therapy

Tongtong Qi et al.

JOURNAL OF DRUG TARGETING (2020)

Review Cell Biology

Memory T cells: strategies for optimizing tumor immunotherapy

Qingjun Liu et al.

PROTEIN & CELL (2020)

Review Pharmacology & Pharmacy

Near-infrared fluorescence imaging in immunotherapy

Yuanyuan Ji et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Chemistry, Physical

Recent advances in nanomaterials for sonodynamic therapy

Ting Xu et al.

NANO RESEARCH (2020)

Article Biochemistry & Molecular Biology

The tumor microenvironment

Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

Review Chemistry, Analytical

Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy

Shiya Chen et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Multifunctional sonosensitizers in sonodynamic cancer therapy

Subin Son et al.

CHEMICAL SOCIETY REVIEWS (2020)

Review Oncology

Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy

Mohammad Hassan Baig et al.

SEMINARS IN CANCER BIOLOGY (2019)

Review Chemistry, Inorganic & Nuclear

Dual function luminescent transition metal complexes for cancer theranostics: The combination of diagnosis and therapy

Chung-Nga Ko et al.

COORDINATION CHEMISTRY REVIEWS (2019)

Article Chemistry, Multidisciplinary

A Hypoxia-Responsive Albumin-Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

Guangbao Yang et al.

ADVANCED MATERIALS (2019)

Review Nanoscience & Nanotechnology

Hypoxia-active nanoparticles used in tumor theranostic

Yaqin Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Nanoscience & Nanotechnology

Cancer nanomedicine for combination cancer immunotherapy

Jutaek Nam et al.

NATURE REVIEWS MATERIALS (2019)

Review Nanoscience & Nanotechnology

Nanovaccines for cancer immunotherapy

Yu Zhang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Functionalized Holmium-Doped Hollow Silica Nanospheres for Combined Sonodynamic and Hypoxia-Activated Therapy

Yanke Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Review Radiology, Nuclear Medicine & Medical Imaging

Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI

James P. B. O'Connor et al.

BRITISH JOURNAL OF RADIOLOGY (2019)

Article Chemistry, Multidisciplinary

Metal-Organic-Framework-Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy

Xueting Pan et al.

ADVANCED MATERIALS (2018)

Review Chemistry, Multidisciplinary

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

Xingshu Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biochemistry & Molecular Biology

Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies

Yoichi Takakusagi et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Chemistry, Multidisciplinary

Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

Guangxu Lan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Multidisciplinary Sciences

Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

SCIENCE (2018)

Review Biochemistry & Molecular Biology

The Validation Path of Hypoxia PET Imaging: Focus on Brain Tumours

Natale Quartuccio et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor

Hong Wang et al.

MOLECULAR CELL (2018)

Editorial Material Multidisciplinary Sciences

Chemotherapy and tumor immunity

Stephanie Cornen et al.

SCIENCE (2018)

Article Oncology

The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules

Kimberly M. Arnold et al.

CANCER GROWTH AND METASTASIS (2018)

Article Medicine, Research & Experimental

Nanosonosensitizers for Highly Efficient Sonodynamic Cancer Theranostics

Ju Huang et al.

THERANOSTICS (2018)

Review Materials Science, Multidisciplinary

Near-Infrared Fluorescent Nanomaterials for Bioimaging and Sensing

Philipp Reineck et al.

ADVANCED OPTICAL MATERIALS (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

[18F]-FMISO PET study of hypoxia in gliomas before surgery: correlation with molecular markers of hypoxia and angiogenesis

Lien Bekaert et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2017)

Article Chemistry, Multidisciplinary

Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy

Wen Piao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Multidisciplinary

Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance

Hao Tian et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Oncology

Reliable Biomarkers to Identify New and Recurrent Cancer

Edward R. Sauter

EUROPEAN JOURNAL OF BREAST HEALTH (2017)

Review Chemistry, Multidisciplinary

Tissue-Specific Near-Infrared Fluorescence Imaging

Eric A. Owens et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

Chenggen Qian et al.

ADVANCED MATERIALS (2016)

Review Biotechnology & Applied Microbiology

Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

Akhil Patel et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Oncology

Nanoparticles in radiation oncology: From bench-side to bedside

Chloe Rancoule et al.

CANCER LETTERS (2016)

Review Chemistry, Multidisciplinary

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Zijian Zhou et al.

CHEMICAL SOCIETY REVIEWS (2016)

Review Pharmacology & Pharmacy

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Caroline Wigerup et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Chemistry, Multidisciplinary

Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

Conor McEwan et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

Cell membrane-camouflaged nanoparticles for drug delivery

Brian T. Luk et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

Huachao Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Oncology

Broad targeting of angiogenesis for cancer prevention and therapy

Zongwei Wang et al.

SEMINARS IN CANCER BIOLOGY (2015)

Review Engineering, Multidisciplinary

Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfl uorocarbon Emulsions

Anne H. Schmieder et al.

ENGINEERING (2015)

Review Biochemistry & Molecular Biology

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Joseph C. Walsh et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Engineering, Biomedical

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

Thavasyappan Thambi et al.

BIOMATERIALS (2014)

Review Oncology

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Daniele M. Gilkes et al.

NATURE REVIEWS CANCER (2014)

Article Multidisciplinary Sciences

Particle shape enhances specificity of antibody-displaying nanoparticles

Sutapa Barua et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

Poornima Kolhar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

The tumor microenvironment at a glance

Frances R. Balkwill et al.

JOURNAL OF CELL SCIENCE (2012)

Review Oncology

Hyperbaric oxygen therapy and cancer-a review

Ingrid Moen et al.

TARGETED ONCOLOGY (2012)

Editorial Material Chemistry, Multidisciplinary

Theranostic Nanomedicine

Xiaoyuan Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Oncology

Targeting hypoxia in cancer therapy

William R. Wilson et al.

NATURE REVIEWS CANCER (2011)

Review Pharmacology & Pharmacy

Nanoparticle-based theranostic agents

Jin Xie et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

Article Chemistry, Multidisciplinary

Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia

Kazuki Kiyose et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Review Radiology, Nuclear Medicine & Medical Imaging

Molecular imaging of hypoxia with radiolabelled agents

Gilles Mees et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2009)

Article Multidisciplinary Sciences

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

KangAe Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Oncology

Reproducibility of intratumor distribution of F-18-fluoromisonidazole in head and neck cancer

Sadek A. Nehmeh et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2008)

Article Medicine, Research & Experimental

Factors affecting the clearance and biodistribution of polymeric nanoparticles

Frank Alexis et al.

MOLECULAR PHARMACEUTICS (2008)

Review Oncology

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2008)

Review Biochemistry & Molecular Biology

Detection and characterization of tumor hypoxia using pO2 histography

Peter Vaupel et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Review Oncology

Targeting hypoxia cell signaling for cancer therapy

Giovanni Melillo

CANCER AND METASTASIS REVIEWS (2007)

Review Oncology

Breast cancer metastasis: Markers and models

B Weigelt et al.

NATURE REVIEWS CANCER (2005)