4.7 Article

TANNylation of mesoporous silica nanoparticles and bioactivity profiling in intestinal cells

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Inositol-Requiring Kinase 1 Regulates Apoptosis via Inducing Endoplasmic Reticulum Stress in Colitis Epithelial Cells

Bei Zhang et al.

Summary: ERS, particularly the role of IRE-1, was analyzed in UC mucosa tissue and cell lines, revealing its involvement in regulating cell proliferation, apoptosis, and response to IL-6-induced ERS. Targeting IRE-1 could enhance unfolded protein response and apoptosis in UC, suggesting its potential as a therapeutic target.

DIGESTIVE DISEASES AND SCIENCES (2021)

Article Chemistry, Physical

Facile Synthesis of Spatially-Functionalized Core-Shell Nanocatalysts with 3-D Mesopore Structure

Cornelia Baeckmann et al.

Summary: Hollow mesoporous silica particles (HMSPs) are promising nanocatalysts for greener chemical processes, with improved synthesis methods resulting in precise control over size and pore structure. Additionally, selective functionalization with amine groups has been achieved through optimized extraction protocols.

CHEMCATCHEM (2021)

Review Chemistry, Multidisciplinary

Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Zimu Li et al.

Summary: The impermeable barrier of solid tumors poses challenges for the clinical translation of nanomedicine. Surface modification strategies, particularly those utilizing direct contact between surfaces, offer a promising solution for improving penetrability. However, further research is needed to address evaluation methods and existing challenges in this field.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Charge-reversal biodegradable MSNs for tumor synergetic chemo/ photothermal and visualized therapy

Zimu Li et al.

Summary: A novel nanomedicine, MSN-Man-DOX@PDA-Gd-PEOz, was developed with excellent tumor targeting and penetration abilities, showing outstanding therapeutic effects in vivo and a promising prospect for clinical application.

JOURNAL OF CONTROLLED RELEASE (2021)

Editorial Material Nanoscience & Nanotechnology

Clinical translation of silica nanoparticles

Taskeen Iqbal Janjua et al.

Summary: Silica nanoparticles have shown promising safety, efficacy, and viability in clinical trials for various biomedical applications such as oral drug delivery, diagnostics, and therapy, indicating their potential in the field.

NATURE REVIEWS MATERIALS (2021)

Article Chemistry, Physical

On the importance of the linking chemistry for the PEGylation of mesoporous silica nanoparticles

Cornelia von Baeckmann et al.

Summary: This study compared different PEGylation methods for functionalizing mesoporous silica nanoparticles. The results indicate that the choice of coupling method strongly influences the grafting efficiency and resulting protein adsorption. This highlights the importance of selecting the right linking chemistry for surface functionalization of nanoparticles.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Pharmacology & Pharmacy

Endoplasmic Reticulum Adaptation and Autophagic Competence Shape Response to Fluid Shear Stress in T24 Bladder Cancer Cells

Giorgia Del Favero et al.

Summary: Accumulation of xenobiotics and waste metabolites in the urinary bladder is constantly accompanied by shear stress, which modulates cellular response in both health and disease. T24 urinary bladder cancer cells respond to shear stress by increasing surface area, with further enhancement when exposed to DON-3-Sulf. ER reshaping and cytoskeletal rearrangement play key roles in the physical/chemical response potential of bladder cells in response to biomechanical stimulation.

FRONTIERS IN PHARMACOLOGY (2021)

Article Chemistry, Multidisciplinary

Evaporation-Induced Self-Assembly of Small Peptide-Conjugated Silica Nanoparticles

Cornelia Baeckmann et al.

Summary: The study introduces a unique evaporation-induced self-assembly (EISA) strategy for four different silica nanoparticle systems obtained through peptide functionalization of the particle surface. The research shows that this EISA-based approach provides new possibilities for the design of future advanced drug delivery systems, engineered hierarchical sorbents, and nanocatalyst assemblies.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Physical

Insights into the intraparticle morphology of dendritic mesoporous silica nanoparticles from electron tomographic reconstructions

Janika Hochstrasser et al.

Summary: The study focuses on fine-tuning the morphology of dendritic mesoporous silica nanoparticles (DMSNs) and successfully demonstrates the independent tuning of particle and pore sizes. The unique morphological features influencing guest molecule interactions were uncovered through detailed analysis.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Materials Science, Biomaterials

Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin

John Ndayishimiye et al.

Summary: The development of silica nanoparticles-based formulations enhances the epithelial permeability of Vancomycin. Silica nanoparticles with large pores and functionalized with -CH3 groups show prolonged release and permeation enhancing effect. This study highlights the potential of silica nanoparticles, especially those with large pores, for oral delivery of Vancomycin or other antimicrobial peptides.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Oncology

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Xi Chen et al.

Summary: This review explores how ER stress in the tumor microenvironment can influence the functions of cancer cells and immune cells, leading to vulnerabilities that could be targeted by emerging therapeutic strategies. The tightly regulated processes of protein handling, modification, and folding in the ER determine cell function and survival, and disruptions in ER homeostasis can result in a state of persistent ER stress with pro-tumoral effects in cancer cells and immunomodulatory effects in immune cells.

NATURE REVIEWS CANCER (2021)

Article Chemistry, Multidisciplinary

Smart Protein-Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin

Estelle Juere et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Article Multidisciplinary Sciences

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Prashanth K. B. Nagesh et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Multidisciplinary

Development of Mesoporous Silica Nanoparticles of Tunable Pore Diameter for Superior Gemcitabine Drug Delivery in Pancreatic Cancer Cells

Kusum Saini et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2020)

Article Chemistry, Multidisciplinary

Multimodality Imaging of Silica and Silicon Materials In Vivo

Didem Sen Karaman et al.

ADVANCED MATERIALS (2018)

Article Pharmacology & Pharmacy

Tannic acid (TA): A molecular tool for chelating and imaging labile iron

Isara Phiwchai et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Engineering, Biomedical

Targeting protein and peptide therapeutics to the heart via tannic acid modification

Mikyung Shin et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Article Chemistry, Physical

Talented Mesoporous Silica Nanoparticles

Karin Moeller et al.

CHEMISTRY OF MATERIALS (2017)

Article Chemistry, Medicinal

Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins

Yuee Cai et al.

MEDICINAL RESEARCH REVIEWS (2017)

Article Materials Science, Biomaterials

Antibody-conjugated mesoporous silica nanoparticles for brain microvessel endothelial cell targeting

Meryem Bouchoucha et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Article Chemistry, Multidisciplinary

A Drug-Self-Gated Mesoporous Antitumor Nanoplatform Based on pH-Sensitive Dynamic Covalent Bond

Xiaowei Zeng et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Chemistry, Analytical

Elucidation of the Fe(III) Gallate Structure in Historical Iron Gall Ink

Aldo Ponce et al.

ANALYTICAL CHEMISTRY (2016)

Article Chemistry, Applied

Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior

Natalia I. Cuello et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2015)

Review Biochemistry & Molecular Biology

Tilting Plant Metabolism for Improved Metabolite Biosynthesis and Enhanced Human Benefit

Bhekumthetho Ncube et al.

MOLECULES (2015)

Article Chemistry, Multidisciplinary

Dendrimer-like hybrid particles with tunable hierarchical pores

Xin Du et al.

NANOSCALE (2015)

Article Engineering, Chemical

Physical Adsorption Characterization of Nanoporous Materials

Matthias Thommes

CHEMIE INGENIEUR TECHNIK (2010)

Article Chemistry, Multidisciplinary

Cavitation in Metastable Liquid Nitrogen Confined to Nanoscale Pores

Christopher J. Rasmussen et al.

LANGMUIR (2010)

Review Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery

Juan L. Vivero-Escoto et al.

SMALL (2010)