Multi-detection method for the fast screening of bisphenol A diglycidyl ether conjugates in the can-coating material

Untargeted screening high-pressure liquid chromatography-mass spectrometry method for the bisphenol A diglycidyl ether conjugates (BADGEs) present in the can-coating material was developed. The method was based on the detection of ions [M+H](+), [M+NH4](+), [M+Na](+) and the respective product ions formed as a result of the cone voltage-induced fragmentation, mainly those at m/z 135, 191, and 207. The method allowed the detection of the most common and most abundant BADGEs present in the can-coating materials, namely H2O, BuEtOH, and BPA adducts.

Automated summary

We developed an untargeted screening method using high-pressure liquid chromatography-mass spectrometry to detect BADGEs in can-coating materials, specifically targeting the most common and abundant BADGEs such as H2O, BuEtOH, and BPA adducts.